Tocumen International offers nonstop service to 192 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| David | DAV | Panama | 343 km | 1h 8m | CM |
| Cartagena | CTG | Colombia | 451 km | 1h 13m | CM |
| San Andres Island | ADZ | Colombia | 464 km | 1h 17m | CM |
| San Jose | SJO | Costa Rica | 538 km | 1h 25m | AV, CM |
| Medellin | MDE | Colombia | 541 km | 1h 22m | CM |
| Barranquilla | BAQ | Colombia | 543 km | 1h 16m | CM |
| Santa Marta | SMR | Colombia | 608 km | 1h 27m | CM |
| Pereira | PEI | Colombia | 619 km | 1h 26m | CM |
| Cali | CLO | Colombia | 695 km | 1h 39m | CM |
| Bucaramanga | BGA | Colombia | 716 km | 1h 31m | CM |
| Bogota | BOG | Colombia | 754 km | 1h 40m | AV, CM |
| Cucuta | CUC | Colombia | 767 km | 1h 40m | CM |
| Managua | MGA | Nicaragua | 816 km | 1h 44m | CM |
| Maracaibo | MAR | Venezuela | 856 km | 1h 44m | CM |
| Kingston | KIN | Jamaica | 1,020 km | 1h 55m | CM |
| Quito | UIO | Ecuador | 1,022 km | 2h 1m | CM |
| Montego Bay | MBJ | Jamaica | 1,055 km | 2h 2m | CM |
| Comayagua | XPL | Honduras | 1,074 km | 1h 59m | CM |
| Aruba | AUA | Aruba | 1,093 km | 1h 57m | CM |
| Barquisimeto | BRM | Venezuela | 1,106 km | 2h 3m | CM |
| Manta | MEC | Ecuador | 1,117 km | 2h 1m | CM |
| Grand Cayman Island | GCM | Cayman Islands | 1,151 km | 2h 0m | KX |
| San Salvador | SAL | El Salvador | 1,161 km | 2h 7m | AV, CM |
| San Pedro Sula | SAP | Honduras | 1,166 km | 2h 11m | CM |
| Curacao | CUR | Curaçao | 1,191 km | 2h 6m | CM |
| Guayaquil | GYE | Ecuador | 1,240 km | 2h 17m | CM |
| Valencia | VLN | Venezuela | 1,264 km | 2h 10m | CM, T9 |
| Belize City | BZE | Belize | 1,345 km | 2h 27m | CM |
| Guatemala City | GUA | Guatemala | 1,358 km | 2h 23m | CM |
| Caracas | CCS | Venezuela | 1,368 km | 2h 23m | CM |
| Santo Domingo | SDQ | Dominican Republic | 1,474 km | 2h 24m | CM |
| Santiago | STI | Dominican Republic | 1,484 km | 2h 27m | CM |
| Puerto Plata | POP | Dominican Republic | 1,516 km | 2h 26m | CM |
| Cancun | CUN | Mexico | 1,549 km | 2h 48m | CM |
| Havana | HAV | Cuba | 1,575 km | 2h 35m | CM |
| Punta Cana | PUJ | Dominican Republic | 1,587 km | 2h 34m | CM |
| Barcelona | BLA | Venezuela | 1,617 km | 2h 43m | CM |
| Porlamar | PMV | Venezuela | 1,702 km | 2h 46m | CM |
| Chiclayo | CIX | Peru | 1,754 km | 2h 55m | CM |
| San Juan | SJU | Puerto Rico | 1,778 km | 2h 50m | CM |
| Nassau | NAS | Bahamas | 1,780 km | 2h 57m | CM |
| Miami | MIA | USA | 1,853 km | 3h 8m | AA, CM |
| Fort Lauderdale | FLL | USA | 1,883 km | 3h 16m | CM |
| Port Of Spain | POS | Trinidad and Tobago | 1,986 km | 3h 5m | CM |
| Sint Maarten | SXM | Sint Maarten | 2,020 km | 3h 3m | CM |
| Pointe-a-Pitre | PTP | Guadeloupe | 2,095 km | 3h 5m | AF |
| Tampa | TPA | USA | 2,119 km | 3h 23m | CM |
| Orlando | MCO | USA | 2,153 km | 3h 32m | CM |
| Bridgetown | BGI | Barbados | 2,218 km | 3h 18m | CM |
| Lima | LIM | Peru | 2,346 km | 3h 39m | CM |
| Georgetown | GEO | Guyana | 2,347 km | 3h 31m | CM |
| Mexico City | MEX | Mexico | 2,410 km | 3h 48m | AM, CM |
| Manaus | MAO | Brazil | 2,528 km | 3h 53m | CM |
| Paramaribo | PBM | Suriname | 2,701 km | 4h 3m | CM |
| Atlanta | ATL | USA | 2,770 km | 4h 15m | CM, DL |
| Houston | IAH | USA | 2,849 km | 4h 22m | UA |
| Guadalajara | GDL | Mexico | 2,864 km | 4h 23m | CM |
| Monterrey | MTY | Mexico | 2,867 km | 4h 31m | CM |
| Raleigh/Durham | RDU | USA | 2,969 km | 4h 26m | CM |
| Austin | AUS | USA | 3,014 km | 4h 42m | CM |
| Dulles | IAD | USA | 3,316 km | 4h 48m | CM |
| Baltimore | BWI | USA | 3,346 km | 4h 52m | CM |
| Santa Cruz | VVI | Bolivia | 3,452 km | 4h 57m | CM |
| New York | EWR | USA | 3,541 km | 5h 16m | UA |
| New York | JFK | USA | 3,541 km | 5h 14m | CM |
| San Jose Cabo | SJD | Mexico | 3,587 km | 5h 13m | CM |
| Chicago | ORD | USA | 3,740 km | 5h 39m | CM |
| Boston | BOS | USA | 3,779 km | 5h 38m | CM |
| Toronto | YYZ | Canada | 3,835 km | 5h 33m | CM |
| Salta | SLA | Argentina | 4,043 km | 5h 49m | CM |
| Montreal | YUL | Canada | 4,069 km | 5h 49m | CM |
| Denver | DEN | USA | 4,233 km | 6h 15m | CM |
| Tucuman | TUC | Argentina | 4,261 km | 6h 2m | CM |
| Brasilia | BSB | Brazil | 4,431 km | 6h 16m | CM |
| Asuncion | ASU | Paraguay | 4,475 km | 6h 8m | CM |
| San Diego | SAN | USA | 4,684 km | 6h 37m | CM |
| Las Vegas | LAS | USA | 4,692 km | 6h 48m | CM |
| Cordoba | COR | Argentina | 4,752 km | 6h 34m | CM |
| Mendoza | MDZ | Argentina | 4,770 km | 6h 35m | CM |
| Santiago | SCL | Chile | 4,786 km | 6h 31m | CM |
| Los Angeles | LAX | USA | 4,844 km | 7h 3m | CM |
| Belo Horizonte | CNF | Brazil | 5,015 km | 6h 51m | CM |
| Rosario | ROS | Argentina | 5,049 km | 6h 54m | CM |
| Sao Paulo | GRU | Brazil | 5,074 km | 6h 56m | CM |
| Salvador | SSA | Brazil | 5,148 km | 6h 58m | CM |
| Florianopolis | FLN | Brazil | 5,249 km | 7h 7m | CM |
| Porto Alegre | POA | Brazil | 5,272 km | 7h 10m | CM |
| Rio De Janeiro | GIG | Brazil | 5,287 km | 7h 8m | CM |
| Buenos Aires | EZE | Argentina | 5,330 km | 7h 11m | CM |
| San Francisco | SFO | USA | 5,343 km | 7h 44m | CM |
| Montevideo | MVD | Uruguay | 5,447 km | 7h 15m | CM |
| Calgary | YYC | Canada | 5,636 km | 8h 0m | WS |
| Madrid | MAD | Spain | 8,163 km | 10h 5m | IB, UX |
| Paris | CDG | France | 8,667 km | 10h 25m | AF |
| Amsterdam | AMS | Netherlands | 8,818 km | 10h 25m | KL |
| Istanbul | IST | Turkiye | 10,831 km | 12h 45m | TK |