Juan Santamaria International offers nonstop service to 53 destinations, served by 29 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Quepos | XQP | Costa Rica | 61 km | 0h 30m | RZ, GW |
| Fortuna | FON | Costa Rica | 66 km | 0h 30m | RZ |
| Tortuquero | TTQ | Costa Rica | 98 km | 0h 35m | RZ |
| Cobano | ACO | Costa Rica | 103 km | 0h 40m | GW, RZ |
| Limon | LIO | Costa Rica | 129 km | 0h 45m | RZ |
| Drake Bay | DRK | Costa Rica | 154 km | 0h 50m | RZ |
| Nosara Beach | NOB | Costa Rica | 158 km | 0h 45m | RZ, GW |
| Guanacaste | LIR | Costa Rica | 160 km | 0h 50m | RZ, WK |
| Tamarindo | TNO | Costa Rica | 179 km | 0h 50m | RZ |
| Golfito | GLF | Costa Rica | 186 km | 1h 0m | RZ |
| Puerto Jimenez | PJM | Costa Rica | 189 km | 0h 55m | RZ, GW |
| Bocas Del Toro | BOC | Panama | 226 km | 1h 3m | RZ |
| Managua | MGA | Nicaragua | 320 km | 1h 7m | CM, RZ |
| Panama City | PTY | Panama | 538 km | 1h 24m | AV, CM |
| San Salvador | SAL | El Salvador | 652 km | 1h 20m | AV, Q6, N3 |
| Guatemala City | GUA | Guatemala | 855 km | 1h 35m | AV, CM, Q6 |
| Cartagena | CTG | Colombia | 953 km | 1h 45m | AV |
| Medellin | MDE | Colombia | 1,055 km | 2h 5m | AV, P5 |
| Cancun | CUN | Mexico | 1,254 km | 2h 19m | Q6, Y4 |
| Bogota | BOG | Colombia | 1,255 km | 2h 15m | AV |
| Quito | UIO | Ecuador | 1,293 km | 2h 20m | AV |
| Guayaquil | GYE | Ecuador | 1,425 km | 2h 28m | AV |
| Miami | MIA | USA | 1,796 km | 3h 5m | AA, AV, N3, Q6 |
| Santo Domingo | SDQ | Dominican Republic | 1,822 km | 2h 57m | DM |
| Fort Lauderdale | FLL | USA | 1,829 km | 2h 58m | B6, NK |
| Mexico City | MEX | Mexico | 1,909 km | 3h 0m | AM, AV, Q6 |
| Orlando | MCO | USA | 2,063 km | 3h 20m | B6, NK, F9, WN, Q6 |
| Guadalajara | GDL | Mexico | 2,356 km | 3h 35m | Q6 |
| Monterrey | MTY | Mexico | 2,422 km | 3h 45m | VB |
| Houston | HOU | USA | 2,461 km | 3h 40m | WN |
| Houston | IAH | USA | 2,496 km | 3h 54m | UA |
| Lima | LIM | Peru | 2,558 km | 3h 45m | LA |
| Atlanta | ATL | USA | 2,618 km | 4h 10m | DL, F9 |
| Charlotte | CLT | USA | 2,812 km | 4h 34m | AA |
| Dallas | DFW | USA | 2,857 km | 4h 37m | AA |
| Nashville | BNA | USA | 2,905 km | 4h 25m | WN |
| Dulles | IAD | USA | 3,277 km | 4h 43m | UA |
| Baltimore | BWI | USA | 3,318 km | 4h 45m | WN |
| New York | EWR | USA | 3,541 km | 5h 13m | UA |
| New York | JFK | USA | 3,547 km | 5h 0m | B6 |
| Chicago | ORD | USA | 3,561 km | 5h 30m | UA, AA |
| Toronto | YYZ | Canada | 3,759 km | 5h 15m | AC, TS |
| Denver | DEN | USA | 3,878 km | 5h 42m | UA, WN |
| Montreal | YUL | Canada | 4,055 km | 5h 40m | AC, TS |
| Las Vegas | LAS | USA | 4,253 km | 5h 55m | WN |
| Los Angeles | LAX | USA | 4,380 km | 6h 30m | AS, DL, UA |
| San Francisco | SFO | USA | 4,892 km | 7h 1m | UA |
| Madrid | MAD | Spain | 8,506 km | 10h 10m | IB, E9 |
| London | LGW | United Kingdom | 8,733 km | 10h 25m | BA |
| Paris | CDG | France | 8,942 km | 10h 30m | AF |
| Amsterdam | AMS | Netherlands | 9,065 km | 10h 35m | KL |
| Frankfurt | FRA | Germany | 9,361 km | 11h 13m | LH |
| Zurich | ZRH | Switzerland | 9,404 km | 10h 50m | WK |