Gregorio Luperon International offers nonstop service to 15 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Santo Domingo | SDQ | Dominican Republic | 173 km | 0h 50m | DE |
| Montego Bay | MBJ | Jamaica | 786 km | 1h 40m | WK |
| Miami | MIA | USA | 1,200 km | 2h 18m | AA |
| Panama City | PTY | Panama | 1,516 km | 2h 42m | CM |
| Charlotte | CLT | USA | 1,993 km | 3h 37m | AA |
| Atlanta | ATL | USA | 2,063 km | 3h 36m | DL |
| New York | JFK | USA | 2,335 km | 3h 49m | B6 |
| New York | EWR | USA | 2,346 km | 3h 54m | UA |
| Boston | BOS | USA | 2,507 km | 3h 59m | B6 |
| Toronto | YYZ | Canada | 2,784 km | 4h 25m | AC, TS, WS |
| Halifax | YHZ | Canada | 2,862 km | 4h 5m | TS |
| Montreal | YUL | Canada | 2,865 km | 4h 15m | AC, TS, WS |
| Ottawa | YOW | Canada | 2,874 km | 4h 20m | TS |
| Quebec | YQB | Canada | 2,999 km | 4h 20m | TS, WS |
| Calgary | YYC | Canada | 5,140 km | 7h 46m | WS |