Gregorio Luperon International offers nonstop service to 33 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Santo Domingo | SDQ | Dominican Republic | 173 km | 0h 50m | DE |
| Punta Cana | PUJ | Dominican Republic | 266 km | 1h 0m | DE |
| Montego Bay | MBJ | Jamaica | 786 km | 1h 45m | WK |
| Miami | MIA | USA | 1,200 km | 2h 20m | AA |
| Panama City | PTY | Panama | 1,516 km | 2h 40m | CM |
| Charlotte | CLT | USA | 1,993 km | 3h 33m | AA |
| Atlanta | ATL | USA | 2,063 km | 3h 33m | DL |
| New York | JFK | USA | 2,335 km | 3h 46m | B6 |
| New York | EWR | USA | 2,346 km | 3h 55m | UA |
| Boston | BOS | USA | 2,507 km | 4h 2m | B6 |
| London | YXU | Canada | 2,764 km | 4h 10m | TS |
| Toronto | YYZ | Canada | 2,784 km | 4h 30m | AC, TS, WS |
| Halifax | YHZ | Canada | 2,862 km | 4h 5m | TS |
| Montreal | YUL | Canada | 2,865 km | 4h 15m | AC, TS |
| Ottawa | YOW | Canada | 2,874 km | 4h 20m | TS |
| Quebec | YQB | Canada | 2,999 km | 4h 20m | TS, WS |
| Calgary | YYC | Canada | 5,140 km | 7h 45m | WS |