Las Americas International offers nonstop service to 44 destinations, served by 22 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Punta Cana | PUJ | Dominican Republic | 139 km | 0h 35m | TX |
| San Juan | SJU | Puerto Rico | 387 km | 1h 2m | B6, F9, DM |
| Providenciales | PLS | Turks and Caicos Islands | 458 km | 1h 20m | JY |
| Saint Thomas | STT | U.S. Virgin Islands | 497 km | 1h 10m | DO |
| Beef Island | EIS | British Virgin Islands | 542 km | 1h 30m | JY |
| Aruba | AUA | Aruba | 656 km | 1h 26m | DM |
| Santiago | SCU | Cuba | 669 km | 0h 20m | DO |
| Curacao | CUR | Curaçao | 694 km | 1h 20m | L5 |
| Sint Maarten | SXM | Sint Maarten | 695 km | 1h 27m | DM |
| Anguilla | AXA | Anguilla | 700 km | 1h 0m | DO |
| Bonaire | BON | Caribbean Netherlands | 712 km | 1h 20m | DO |
| Saint Kitts | SKB | St. Kitts and Nevis | 748 km | 1h 25m | DO |
| Kingston | KIN | Jamaica | 754 km | 1h 38m | DM |
| Antigua | ANU | Antigua and Barbuda | 848 km | 1h 48m | DO, S6, 5L |
| Pointe-a-Pitre | PTP | Guadeloupe | 898 km | 1h 30m | DO |
| Maracaibo | MAR | Venezuela | 898 km | 1h 30m | 5R |
| Barquisimeto | BRM | Venezuela | 928 km | 1h 30m | 5R |
| Fort De France | FDF | Martinique | 1,018 km | 1h 30m | DO |
| Cartagena | CTG | Colombia | 1,084 km | 2h 2m | DM |
| Maturin | MUN | Venezuela | 1,190 km | 1h 30m | 5R |
| Miami | MIA | USA | 1,363 km | 2h 33m | AA, F9, DO, DM |
| Fort Lauderdale | FLL | USA | 1,370 km | 2h 27m | B6, NK |
| Havana | HAV | Cuba | 1,418 km | 1h 20m | DO |
| Panama City | PTY | Panama | 1,474 km | 2h 35m | CM |
| Medellin | MDE | Colombia | 1,492 km | 2h 30m | P5, DM |
| Bogota | BOG | Colombia | 1,594 km | 2h 40m | AV, P5, DM |
| Orlando | MCO | USA | 1,622 km | 2h 52m | B6, F9 |
| Tampa | TPA | USA | 1,686 km | 2h 54m | F9 |
| Georgetown | GEO | Guyana | 1,810 km | 2h 30m | DO |
| San Jose | SJO | Costa Rica | 1,822 km | 3h 8m | DM |
| Paramaribo | PBM | Suriname | 2,130 km | 3h 0m | DO |
| Atlanta | ATL | USA | 2,236 km | 3h 46m | DL, F9 |
| Guatemala City | GUA | Guatemala | 2,265 km | 3h 36m | DM |
| Philadelphia | PHL | USA | 2,436 km | 3h 57m | AA, F9 |
| New York | JFK | USA | 2,493 km | 3h 59m | B6, DL |
| New York | EWR | USA | 2,504 km | 4h 12m | B6, UA, DM |
| Boston | BOS | USA | 2,656 km | 4h 6m | B6, DM, NK |
| Mexico City | NLU | Mexico | 3,087 km | 4h 55m | DM |
| Mexico City | MEX | Mexico | 3,094 km | 5h 3m | AM |
| Lima | LIM | Peru | 3,465 km | 5h 10m | DM |
| Buenos Aires | EZE | Argentina | 6,009 km | 8h 11m | DM |
| Madrid | MAD | Spain | 6,698 km | 8h 15m | IB, UX, 2W |
| Paris | ORY | France | 7,179 km | 8h 30m | TX |
| Frankfurt | FRA | Germany | 7,626 km | 9h 28m | DE |