Santa Cruz offers nonstop service to 19 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Sucre | SRE | Bolivia | 273 km | 0h 45m | OB |
| Cochabamba | CBB | Bolivia | 323 km | 0h 45m | 8J, OB |
| Trinidad | TDD | Bolivia | 365 km | 0h 50m | 8J |
| Oruro | ORU | Bolivia | 418 km | 1h 5m | OB |
| Tarija | TJA | Bolivia | 461 km | 1h 0m | OB |
| La Paz | LPB | Bolivia | 550 km | 1h 5m | OB, 8J |
| Iquique | IQQ | Chile | 807 km | 1h 50m | OB |
| Salta | SLA | Argentina | 832 km | 1h 30m | OB |
| Asuncion | ASU | Paraguay | 1,022 km | 1h 45m | ZP, OB |
| Lima | LIM | Peru | 1,626 km | 2h 45m | LA, OB |
| Sao Paulo | GRU | Brazil | 1,849 km | 2h 55m | G3, OB |
| Santiago | SCL | Chile | 1,905 km | 3h 9m | LA, OB |
| Buenos Aires | AEP | Argentina | 1,931 km | 3h 0m | AR |
| Buenos Aires | EZE | Argentina | 1,955 km | 2h 55m | OB |
| Rio De Janeiro | GIG | Brazil | 2,153 km | 3h 5m | OB |
| Bogota | BOG | Colombia | 2,751 km | 3h 55m | AV |
| Panama City | PTY | Panama | 3,452 km | 4h 49m | CM, OB |
| Miami | MIA | USA | 5,152 km | 6h 50m | OB |
| Madrid | MAD | Spain | 8,903 km | 10h 50m | OB, UX |