Simon Bolivar International offers nonstop service to 53 destinations, served by 17 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Barcelona | BLA | Venezuela | 259 km | 0h 45m | 5R, 9V |
| Barquisimeto | BRM | Venezuela | 264 km | 0h 45m | 5R, 9V |
| Curacao | CUR | Curaçao | 276 km | 0h 53m | 9V, QL |
| Porlamar | PMV | Venezuela | 334 km | 0h 45m | 5R, 9V |
| Las Piedras | LSP | Venezuela | 367 km | 0h 45m | 9V |
| Barinas | BNS | Venezuela | 415 km | 1h 0m | |
| Maturin | MUN | Venezuela | 432 km | 1h 0m | 5R |
| Ciudad Bolivar | CBL | Venezuela | 469 km | 1h 0m | 5R |
| Maracaibo | MAR | Venezuela | 516 km | 1h 10m | 5R, 9V |
| Puerto Ordaz | PZO | Venezuela | 531 km | 1h 18m | 5R, 9V |
| El Vigia | VIG | Venezuela | 554 km | 1h 10m | 9V |
| Port Of Spain | POS | Trinidad and Tobago | 620 km | 1h 50m | BW |
| Santo Domingo | STD | Venezuela | 647 km | 1h 13m | 5R |
| San Antonio del Tachira | SVZ | Venezuela | 670 km | 1h 20m | |
| Punta Cana | PUJ | Dominican Republic | 893 km | 1h 20m | 5R |
| Bogota | BOG | Colombia | 1,022 km | 1h 58m | 9V, AV, LA, P5 |
| Medellin | MDE | Colombia | 1,048 km | 1h 53m | 9V, P5 |
| Panama City | PTY | Panama | 1,368 km | 2h 29m | CM |
| Miami | MIA | USA | 2,187 km | 3h 33m | AA |
| Houston | IAH | USA | 3,636 km | 5h 33m | UA |
| Sao Paulo | GRU | Brazil | 4,377 km | 6h 10m | G3 |
| Tenerife | TFN | Spain | 5,625 km | 7h 20m | PU |
| Funchal | FNC | Portugal | 5,680 km | 7h 20m | TP |
| Lisbon | LIS | Portugal | 6,506 km | 8h 0m | TP |
| Madrid | MAD | Spain | 7,011 km | 8h 30m | IB, PU, QL, UX |
| Istanbul | IST | Turkiye | 9,716 km | 11h 40m | TK |
| Doha | DOH | Qatar | 12,282 km | 14h 5m | QR |