Mariscal Sucre International offers nonstop service to 49 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Coca | OCC | Ecuador | 157 km | 0h 39m | 6G, LA |
| Manta | MEC | Ecuador | 274 km | 0h 49m | AV, LA |
| Guayaquil | GYE | Ecuador | 280 km | 0h 53m | AV, KL, LA |
| Cuenca | CUE | Ecuador | 313 km | 0h 56m | AV, LA |
| Santa Rosa | ETR | Ecuador | 409 km | 0h 50m | 6G |
| Loja | LOH | Ecuador | 442 km | 0h 50m | 6G |
| Bogota | BOG | Colombia | 709 km | 1h 35m | AV, LA |
| Medellin | MDE | Colombia | 768 km | 1h 30m | AV |
| Panama City | PTY | Panama | 1,022 km | 1h 59m | CM |
| San Cristobal | SCY | Ecuador | 1,256 km | 2h 10m | AV |
| San Jose | SJO | Costa Rica | 1,293 km | 2h 15m | AV |
| Lima | LIM | Peru | 1,323 km | 2h 15m | JA, LA |
| Galapagos Islands | GPS | Ecuador | 1,328 km | 2h 10m | AV, LA |
| San Salvador | SAL | El Salvador | 1,909 km | 2h 50m | AV |
| Miami | MIA | USA | 2,875 km | 4h 21m | AA, LA |
| Mexico City | MEX | Mexico | 3,129 km | 4h 40m | AM |
| Santiago | SCL | Chile | 3,767 km | 5h 0m | LA |
| Houston | IAH | USA | 3,787 km | 5h 15m | UA |
| Atlanta | ATL | USA | 3,791 km | 5h 16m | DL |
| Buenos Aires | EZE | Argentina | 4,358 km | 5h 45m | AV |
| New York | JFK | USA | 4,538 km | 6h 20m | AV |
| Toronto | YYZ | Canada | 4,853 km | 6h 10m | AC |
| Montreal | YUL | Canada | 5,069 km | 6h 20m | AC |
| Madrid | MAD | Spain | 8,737 km | 10h 25m | IB, UX |