Piarco offers nonstop service to 52 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Tobago | TAB | Trinidad and Tobago | 81 km | 0h 25m | BW |
| St. George's | GND | Grenada | 162 km | 0h 40m | 5L, BW |
| Saint Vincent | SVD | Saint Vincent and the Grenadines | 283 km | 1h 0m | 5L, BW |
| Bridgetown | BGI | Barbados | 340 km | 1h 0m | BW, JY |
| Saint Lucia | SLU | Saint Lucia | 379 km | 1h 5m | 5L, BW |
| Dominica | DOM | Dominica | 546 km | 1h 20m | LF |
| Georgetown | OGL | Guyana | 550 km | 1h 50m | BW |
| Georgetown | GEO | Guyana | 566 km | 1h 15m | BW |
| Caracas | CCS | Venezuela | 620 km | 1h 55m | BW |
| Pointe-a-Pitre | PTP | Guadeloupe | 626 km | 2h 5m | BW |
| Antigua | ANU | Antigua and Barbuda | 724 km | 1h 40m | 5L, BW |
| Sint Maarten | SXM | Sint Maarten | 844 km | 2h 30m | BW, WM |
| Curacao | CUR | Curaçao | 849 km | 1h 50m | BW |
| Paramaribo | PBM | Suriname | 885 km | 1h 40m | BW |
| Kingston | KIN | Jamaica | 1,852 km | 3h 0m | BW |
| Panama City | PTY | Panama | 1,986 km | 3h 7m | CM |
| Nassau | NAS | Bahamas | 2,336 km | 3h 30m | UP |
| Miami | MIA | USA | 2,609 km | 4h 14m | AA, BW |
| Fort Lauderdale | FLL | USA | 2,616 km | 4h 5m | BW |
| Havana | HAV | Cuba | 2,626 km | 4h 5m | BW |
| Orlando | MCO | USA | 2,869 km | 4h 30m | BW |
| New York | JFK | USA | 3,546 km | 5h 20m | B6, BW |
| New York | EWR | USA | 3,564 km | 5h 39m | UA |
| Toronto | YYZ | Canada | 4,068 km | 6h 5m | AC, BW |
| Houston | IAH | USA | 4,123 km | 6h 3m | UA |
| London | LGW | United Kingdom | 7,100 km | 8h 40m | BA |
| Amsterdam | AMS | Netherlands | 7,463 km | 9h 5m | KL |