Philip S W Goldson International offers nonstop service to 68 destinations, served by 12 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Belize City | TZA | Belize | 12 km | 0h 5m | 2M, 9N |
| Caye Caulker | CUK | Belize | 36 km | 0h 10m | 2M, 9N |
| San Pedro | SPR | Belize | 55 km | 0h 13m | 2M, 9N |
| Dangriga | DGA | Belize | 62 km | 0h 15m | 2M, 9N |
| Placencia | PLJ | Belize | 111 km | 0h 25m | 2M, 9N |
| Punta Gorda | PND | Belize | 167 km | 0h 45m | 9N |
| Roatan | RTB | Honduras | 232 km | 1h 0m | 9N |
| San Pedro Sula | SAP | Honduras | 234 km | 1h 0m | 9N |
| Guatemala City | GUA | Guatemala | 403 km | 1h 20m | 5U |
| Cancun | CUN | Mexico | 415 km | 1h 30m | 9N |
| Miami | MIA | USA | 1,234 km | 2h 19m | AA |
| Fort Lauderdale | FLL | USA | 1,266 km | 2h 10m | |
| Saint Petersburg | PIE | USA | 1,284 km | 2h 15m | |
| Panama City | PTY | Panama | 1,345 km | 2h 24m | CM |
| Orlando | SFB | USA | 1,438 km | 2h 25m | |
| Houston | HOU | USA | 1,516 km | 2h 30m | WN |
| Houston | IAH | USA | 1,552 km | 2h 42m | UA |
| Atlanta | ATL | USA | 1,825 km | 3h 4m | DL |
| Dallas | DFW | USA | 1,913 km | 3h 26m | AA |
| Charlotte | CLT | USA | 2,090 km | 3h 27m | AA |
| Raleigh/Durham | RDU | USA | 2,238 km | 3h 25m | |
| Baltimore | BWI | USA | 2,650 km | 3h 45m | WN |
| Chicago | ORD | USA | 2,709 km | 4h 24m | UA |
| New York | EWR | USA | 2,902 km | 4h 16m | UA |
| Denver | DEN | USA | 2,933 km | 4h 32m | UA, WN |
| Toronto | YYZ | Canada | 3,011 km | 4h 30m | AC, WS |
| Minneapolis | MSP | USA | 3,066 km | 4h 29m | DL, SY |
| Boston | BOS | USA | 3,204 km | 4h 40m | |
| Montreal | YUL | Canada | 3,378 km | 4h 35m | AC |
| Los Angeles | LAX | USA | 3,503 km | 5h 29m | AS |
| Winnipeg | YWG | Canada | 3,678 km | 5h 30m | WS |
| San Francisco | SFO | USA | 3,998 km | 6h 4m | UA |
| Calgary | YYC | Canada | 4,365 km | 6h 25m | WS |
| Seattle | SEA | USA | 4,538 km | 6h 49m | AS |