Norman Manley International Airport offers nonstop service to 20 destinations, served by 15 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Montego Bay | MBJ | Jamaica | 134 km | 0h 50m | 5L |
| Santiago | SCU | Cuba | 246 km | 0h 55m | JY |
| Grand Cayman Island | GCM | Cayman Islands | 505 km | 1h 15m | KX |
| Providenciales | PLS | Turks and Caicos Islands | 636 km | 1h 45m | JY, 9Q |
| Santo Domingo | SDQ | Dominican Republic | 754 km | 1h 35m | DM |
| Nassau | NAS | Bahamas | 790 km | 1h 30m | BW |
| Punta Cana | PUJ | Dominican Republic | 893 km | 1h 48m | DM |
| Miami | MIA | USA | 942 km | 2h 1m | AA |
| Fort Lauderdale | FLL | USA | 965 km | 1h 54m | B6, NK |
| Panama City | PTY | Panama | 1,020 km | 2h 3m | CM |
| Sint Maarten | SXM | Sint Maarten | 1,448 km | 2h 20m | BW |
| Antigua | ANU | Antigua and Barbuda | 1,594 km | 2h 40m | BW, 5L |
| Fort De France | FDF | Martinique | 1,726 km | 2h 45m | BW |
| St. George's | GND | Grenada | 1,740 km | 2h 35m | BW |
| Port Of Spain | POS | Trinidad and Tobago | 1,852 km | 2h 45m | BW |
| Atlanta | ATL | USA | 1,900 km | 3h 10m | DL |
| Bridgetown | BGI | Barbados | 1,931 km | 2h 40m | JY |
| New York | JFK | USA | 2,533 km | 3h 55m | B6, BW |
| Toronto | YYZ | Canada | 2,866 km | 4h 25m | AC, BW, WS, F8 |
| London | LGW | United Kingdom | 7,545 km | 9h 5m | BA |