Princess Juliana International offers nonstop service to 81 destinations, served by 25 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Anguilla | AXA | Anguilla | 19 km | 0h 10m | Q3, WM |
| Saint Barthelemy | SBH | Saint Barthelemy | 31 km | 0h 20m | PV, TX, WM |
| Saba | SAB | Caribbean Netherlands | 44 km | 0h 20m | WM |
| Saint Eustatius | EUX | Caribbean Netherlands | 62 km | 0h 25m | WM |
| Saint Kitts | SKB | St. Kitts and Nevis | 91 km | 0h 40m | 5L, WM |
| Nevis | NEV | St. Kitts and Nevis | 107 km | 0h 35m | WM |
| Beef Island | EIS | British Virgin Islands | 157 km | 0h 45m | 5L, JY, WM |
| Montserrat | MNI | Montserrat | 169 km | 1h 0m | WM |
| Antigua | ANU | Antigua and Barbuda | 171 km | 0h 48m | 5L, S6, WM, Z6 |
| Saint Thomas | STT | U.S. Virgin Islands | 199 km | 0h 55m | LF |
| San Juan | SJU | Puerto Rico | 309 km | 1h 20m | LF |
| Dominica | DOM | Dominica | 336 km | 1h 10m | 5L, WM |
| Saint Lucia | SLU | Saint Lucia | 499 km | 1h 35m | WM |
| Saint Vincent | SVD | Saint Vincent and the Grenadines | 579 km | 1h 50m | WM |
| Bridgetown | BGI | Barbados | 672 km | 2h 0m | BW, JY, WM |
| Santo Domingo | SDQ | Dominican Republic | 695 km | 1h 30m | DM |
| Santo Domingo | JBQ | Dominican Republic | 729 km | 1h 0m | Y2 |
| Port Of Spain | POS | Trinidad and Tobago | 844 km | 1h 40m | BW, KL, WM |
| Curacao | CUR | Curaçao | 902 km | 2h 25m | 7Z, WM |
| Cap Haitien | CAP | Haiti | 975 km | 2h 0m | S6 |
| Georgetown | GEO | Guyana | 1,380 km | 2h 15m | KL |
| Kingston | KIN | Jamaica | 1,448 km | 2h 30m | BW |
| Fort Lauderdale | FLL | USA | 1,967 km | 3h 19m | B6 |
| Miami | MIA | USA | 1,968 km | 3h 35m | AA |
| Panama City | PTY | Panama | 2,020 km | 3h 25m | CM |
| Orlando | MCO | USA | 2,185 km | 3h 48m | WN |
| Charlotte | CLT | USA | 2,593 km | 4h 26m | AA |
| Baltimore | BWI | USA | 2,684 km | 4h 40m | WN |
| Philadelphia | PHL | USA | 2,687 km | 4h 39m | AA |
| Dulles | IAD | USA | 2,701 km | 4h 35m | UA |
| New York | JFK | USA | 2,706 km | 4h 29m | AA, B6, DL |
| New York | EWR | USA | 2,725 km | 4h 47m | UA |
| Atlanta | ATL | USA | 2,739 km | 4h 23m | DL |
| Boston | BOS | USA | 2,799 km | 4h 36m | B6 |
| Montreal | YUL | Canada | 3,196 km | 5h 0m | AC, TS |
| Toronto | YYZ | Canada | 3,237 km | 5h 25m | AC, TS, WS |
| Chicago | ORD | USA | 3,545 km | 6h 1m | AA, UA |
| Minneapolis | MSP | USA | 4,082 km | 6h 20m | SY |
| Paris | ORY | France | 6,728 km | 8h 0m | TX |
| Paris | CDG | France | 6,746 km | 8h 25m | AF |