Ernesto Cortissoz offers nonstop service to 12 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bucaramanga | BGA | Colombia | 451 km | 1h 8m | P5 |
| Medellin | EOH | Colombia | 524 km | 1h 16m | 9R |
| Medellin | MDE | Colombia | 526 km | 1h 20m | AV, LA, P5, JA |
| Panama City | PTY | Panama | 543 km | 1h 26m | CM |
| Balboa | BLB | Panama | 571 km | 1h 19m | P5 |
| Curacao | CUR | Curaçao | 651 km | 2h 0m | 7Z, W2 |
| Bogota | BOG | Colombia | 688 km | 1h 35m | AV, LA, P5, JA |
| Bonaire | BON | Caribbean Netherlands | 722 km | 2h 0m | W2 |
| San Andres Island | ADZ | Colombia | 777 km | 1h 31m | P5, LA |
| Cali | CLO | Colombia | 831 km | 1h 40m | AV |
| Miami | MIA | USA | 1,748 km | 3h 0m | AA, AV |
| Fort Lauderdale | FLL | USA | 1,772 km | 2h 50m | NK |