Palonegro offers nonstop service to 11 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Cucuta | CUC | Colombia | 115 km | 0h 45m | VE |
| Saravena | RVE | Colombia | 143 km | 0h 45m | 9R, VE |
| Arauca | AUC | Colombia | 269 km | 1h 5m | VE |
| Medellin | MDE | Colombia | 270 km | 0h 55m | AV, P5 |
| Medellin | EOH | Colombia | 284 km | 0h 55m | VE |
| Bogota | BOG | Colombia | 288 km | 1h 5m | AV, LA, P5, JA |
| Cartagena | CTG | Colombia | 447 km | 1h 6m | AV, P5 |
| Barranquilla | BAQ | Colombia | 451 km | 1h 8m | P5 |
| Santa Marta | SMR | Colombia | 456 km | 1h 14m | P5 |
| Aruba | AUA | Aruba | 688 km | 1h 29m | P5 |
| Panama City | PTY | Panama | 716 km | 1h 32m | CM |