Los Cabos International offers nonstop service to 112 destinations, served by 17 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Culiacan | CUL | Mexico | 289 km | 0h 53m | VB, Y4 |
| Hermosillo | HMO | Mexico | 670 km | 1h 24m | VB |
| Torreon | TRC | Mexico | 693 km | 1h 22m | VB |
| Guadalajara | GDL | Mexico | 723 km | 1h 32m | VB, Y4 |
| Leon/Guanajuato | BJX | Mexico | 883 km | 1h 36m | Y4 |
| Monterrey | MTY | Mexico | 1,015 km | 1h 50m | VB |
| Queretaro | QRO | Mexico | 1,023 km | 1h 49m | VB |
| Toluca | TLC | Mexico | 1,135 km | 1h 52m | VB, Y4 |
| Phoenix | PHX | USA | 1,160 km | 2h 10m | AA, WN |
| Mexico City | NLU | Mexico | 1,171 km | 2h 0m | VB, XN, Y4 |
| Mexico City | MEX | Mexico | 1,178 km | 2h 17m | AM, VB, Y4 |
| Mexicali | MXL | Mexico | 1,181 km | 2h 0m | Y4 |
| Puebla | PBC | Mexico | 1,259 km | 2h 4m | Y4 |
| Tijuana | TIJ | Mexico | 1,260 km | 2h 9m | VB, Y4 |
| San Diego | SAN | USA | 1,289 km | 2h 18m | AS, WN |
| Santa Ana | SNA | USA | 1,411 km | 2h 35m | WN |
| Austin | AUS | USA | 1,429 km | 2h 25m | AA, DL, WN |
| Los Angeles | LAX | USA | 1,465 km | 2h 40m | AA, AS, DL, UA |
| Las Vegas | LAS | USA | 1,524 km | 2h 45m | WN |
| Houston | HOU | USA | 1,607 km | 2h 25m | WN |
| Houston | IAH | USA | 1,617 km | 2h 34m | UA |
| Dallas | DFW | USA | 1,646 km | 2h 54m | AA |
| Denver | DEN | USA | 1,910 km | 3h 5m | UA, WN |
| San Jose | SJC | USA | 1,960 km | 3h 12m | AS |
| Salt Lake City | SLC | USA | 1,965 km | 3h 12m | DL |
| Oakland | OAK | USA | 2,006 km | 3h 15m | WN |
| San Francisco | SFO | USA | 2,008 km | 3h 15m | AS, UA |
| Sacramento | SMF | USA | 2,058 km | 3h 20m | WN |
| Kansas City | MCI | USA | 2,282 km | 3h 20m | WN |
| Cancun | CUN | Mexico | 2,366 km | 3h 13m | Y4 |
| Saint Louis | STL | USA | 2,519 km | 3h 33m | WN |
| Nashville | BNA | USA | 2,643 km | 3h 35m | WN |
| Atlanta | ATL | USA | 2,725 km | 3h 46m | DL |
| Portland | PDX | USA | 2,747 km | 4h 16m | AS |
| Minneapolis | MSP | USA | 2,838 km | 4h 5m | DL, SY |
| Indianapolis | IND | USA | 2,869 km | 4h 0m | WN |
| Chicago | MDW | USA | 2,904 km | 4h 10m | WN |
| Chicago | ORD | USA | 2,906 km | 4h 16m | AA, UA |
| Seattle | SEA | USA | 2,918 km | 4h 41m | AS, DL |
| Regina | YQR | Canada | 3,058 km | 4h 40m | WS |
| Victoria | YYJ | Canada | 3,075 km | 4h 55m | WS |
| Charlotte | CLT | USA | 3,086 km | 4h 30m | AA |
| Kelowna | YLW | Canada | 3,090 km | 4h 50m | WS |
| Vancouver | YVR | Canada | 3,121 km | 4h 55m | AC, WS |
| Calgary | YYC | Canada | 3,126 km | 4h 45m | WS |
| Winnipeg | YWG | Canada | 3,161 km | 4h 45m | WS |
| Detroit | DTW | USA | 3,227 km | 4h 30m | DL |
| Edmonton | YEG | Canada | 3,362 km | 5h 5m | PD, WS |
| Dulles | IAD | USA | 3,515 km | 4h 38m | UA |
| Toronto | YYZ | Canada | 3,573 km | 4h 50m | AC, PD |
| Panama City | PTY | Panama | 3,587 km | 4h 58m | CM |
| New York | EWR | USA | 3,843 km | 5h 16m | UA |
| New York | JFK | USA | 3,873 km | 5h 20m | B6, DL |
| Ottawa | YOW | Canada | 3,935 km | 5h 15m | PD |
| Montreal | YUL | Canada | 4,077 km | 5h 10m | AC, TS |
| Frankfurt | FRA | Germany | 9,886 km | 11h 25m | DE |