Rafael Nunez offers nonstop service to 24 destinations, served by 19 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bucaramanga | BGA | Colombia | 447 km | 1h 11m | AV, P5 |
| Panama City | PTY | Panama | 451 km | 1h 20m | CM |
| Medellin | MDE | Colombia | 472 km | 1h 15m | AV, P5, JA, TS |
| Balboa | BLB | Panama | 478 km | 1h 10m | P5 |
| Pereira | PEI | Colombia | 623 km | 1h 25m | AV, JA |
| Bogota | BOG | Colombia | 653 km | 1h 30m | AV, LA, P5, JA |
| San Andres Island | ADZ | Colombia | 715 km | 1h 25m | LA, P5 |
| Cali | CLO | Colombia | 769 km | 1h 35m | AV, LA, JA |
| San Jose | SJO | Costa Rica | 953 km | 1h 45m | AV |
| Santo Domingo | SDQ | Dominican Republic | 1,084 km | 2h 0m | DM |
| Miami | MIA | USA | 1,771 km | 3h 10m | AA, AV |
| Fort Lauderdale | FLL | USA | 1,796 km | 2h 58m | B6, NK |
| Lima | LIM | Peru | 2,491 km | 3h 40m | LA, JA |
| Mexico City | MEX | Mexico | 2,718 km | 4h 18m | AM |
| Mexico City | NLU | Mexico | 2,723 km | 4h 14m | VB |
| Atlanta | ATL | USA | 2,725 km | 4h 18m | DL |
| New York | JFK | USA | 3,350 km | 5h 1m | AV, B6 |
| Toronto | YYZ | Canada | 3,704 km | 5h 18m | AC, TS |
| Montreal | YUL | Canada | 3,884 km | 5h 25m | TS, AC |
| Santiago | SCL | Chile | 4,877 km | 7h 35m | AV |
| Madrid | MAD | Spain | 7,739 km | 9h 45m | PU, 2W |
| Amsterdam | AMS | Netherlands | 8,435 km | 9h 40m | KL |
| Zurich | ZRH | Switzerland | 8,717 km | 10h 3m | WK |
| Milan | MXP | Italy | 8,740 km | 10h 5m | NO |