Rafael Nunez offers nonstop service to 61 destinations, served by 22 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Cucuta | CUC | Colombia | 432 km | 1h 25m | VE |
| Bucaramanga | BGA | Colombia | 447 km | 1h 11m | AV, P5, VE |
| Panama City | PTY | Panama | 451 km | 1h 19m | CM |
| Medellin | EOH | Colombia | 467 km | 1h 35m | VE |
| Medellin | MDE | Colombia | 472 km | 1h 17m | AV, JA, P5, TS |
| Balboa | BLB | Panama | 478 km | 1h 11m | P5 |
| Pereira | PEI | Colombia | 623 km | 1h 26m | AV, JA, VE |
| Bogota | BOG | Colombia | 653 km | 1h 30m | AV, JA, LA, P5 |
| Armenia | AXM | Colombia | 663 km | 1h 26m | JA |
| Ibague | IBE | Colombia | 667 km | 1h 50m | VE |
| San Andres Island | ADZ | Colombia | 715 km | 1h 25m | LA, P5 |
| Cali | CLO | Colombia | 769 km | 1h 35m | AV, JA, LA |
| Santo Domingo | SDQ | Dominican Republic | 1,084 km | 1h 58m | DM |
| Miami | MIA | USA | 1,771 km | 3h 9m | AA |
| Fort Lauderdale | FLL | USA | 1,796 km | 3h 1m | B6 |
| Orlando | MCO | USA | 2,080 km | 3h 13m | F9 |
| Lima | LIM | Peru | 2,491 km | 3h 43m | JA, LA |
| Mexico City | MEX | Mexico | 2,718 km | 4h 20m | AM |
| Mexico City | NLU | Mexico | 2,723 km | 4h 13m | VB |
| Atlanta | ATL | USA | 2,725 km | 4h 15m | DL |
| Houston | IAH | USA | 2,984 km | 4h 25m | UA |
| Dulles | IAD | USA | 3,163 km | 4h 40m | UA |
| New York | JFK | USA | 3,350 km | 5h 0m | AV, B6 |
| Toronto | YYZ | Canada | 3,704 km | 5h 20m | AC, TS |
| Montreal | YUL | Canada | 3,884 km | 5h 25m | AC, TS |
| Santiago | SCL | Chile | 4,877 km | 6h 30m | AV |
| Buenos Aires | AEP | Argentina | 5,297 km | 7h 5m | AR |
| Madrid | MAD | Spain | 7,739 km | 10h 1m | 2W, PU |
| Amsterdam | AMS | Netherlands | 8,435 km | 9h 50m | KL |
| Zurich | ZRH | Switzerland | 8,717 km | 10h 0m | WK |
| Milan | MXP | Italy | 8,740 km | 10h 0m | NO |
| Rome | FCO | Italy | 9,060 km | 9h 50m | NO |