San Andres Island offers nonstop service to 8 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Providencia Island | PVA | Colombia | 92 km | 0h 37m | 9R |
| Panama City | PTY | Panama | 464 km | 1h 21m | CM |
| Cartagena | CTG | Colombia | 715 km | 1h 24m | LA, P5 |
| Barranquilla | BAQ | Colombia | 777 km | 1h 30m | P5, LA |
| Medellin | MDE | Colombia | 988 km | 1h 51m | AV, LA, JA |
| Cali | CLO | Colombia | 1,159 km | 2h 7m | AV, LA, JA |
| Bogota | BOG | Colombia | 1,204 km | 2h 5m | AV, LA, JA |
| Montreal | YUL | Canada | 3,720 km | 5h 22m | WS |