San Andres Island offers nonstop service to 14 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Providencia Island | PVA | Colombia | 92 km | 0h 45m | 9R |
| Panama City | PTY | Panama | 464 km | 1h 15m | CM |
| Cartagena | CTG | Colombia | 715 km | 1h 20m | LA, P5 |
| Barranquilla | BAQ | Colombia | 777 km | 1h 29m | LA, P5 |
| Medellin | MDE | Colombia | 988 km | 1h 50m | AV, JA, LA |
| Cali | CLO | Colombia | 1,159 km | 2h 0m | AV, JA, LA |
| Bogota | BOG | Colombia | 1,204 km | 2h 10m | AV, JA, LA |