Simon Bolivar International offers nonstop service to 16 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Cuenca | CUE | Ecuador | 129 km | 0h 49m | LA |
| Quito | UIO | Ecuador | 280 km | 0h 51m | AV, LA |
| Bogota | BOG | Colombia | 989 km | 1h 55m | AV |
| Medellin | MDE | Colombia | 1,044 km | 1h 50m | AV |
| San Cristobal | SCY | Ecuador | 1,092 km | 1h 48m | AV, LA |
| Lima | LIM | Peru | 1,134 km | 1h 55m | LA |
| Galapagos Islands | GPS | Ecuador | 1,172 km | 1h 57m | AV, LA |
| Panama City | PTY | Panama | 1,240 km | 2h 12m | CM |
| San Jose | SJO | Costa Rica | 1,425 km | 2h 25m | AV |
| Miami | MIA | USA | 3,091 km | 4h 37m | AA, AV |
| Fort Lauderdale | FLL | USA | 3,121 km | 4h 29m | NK, B6 |
| Santiago | SCL | Chile | 3,587 km | 4h 51m | LA |
| Buenos Aires | EZE | Argentina | 4,239 km | 5h 38m | AV |
| New York | JFK | USA | 4,778 km | 6h 40m | B6, AV, LA |
| Madrid | MAD | Spain | 9,012 km | 11h 0m | UX, IB |
| Amsterdam | AMS | Netherlands | 9,830 km | 11h 20m | KL |