Palmerola Air Base offers nonstop service to 9 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| San Salvador | SAL | El Salvador | 189 km | 0h 50m | AV |
| Panama City | PTY | Panama | 1,074 km | 2h 6m | CM |
| Mexico City | MEX | Mexico | 1,340 km | 2h 40m | AM |
| Miami | MIA | USA | 1,474 km | 2h 35m | AA |
| Fort Lauderdale | FLL | USA | 1,507 km | 2h 27m | NK |
| Houston | IAH | USA | 1,897 km | 3h 5m | UA |
| Dallas | DFW | USA | 2,258 km | 3h 50m | AA |
| Madrid | MAD | Spain | 8,486 km | 10h 30m | E9 |
| Barcelona | BCN | Spain | 8,941 km | 10h 50m | E9 |