Eduardo Gomes International offers nonstop service to 25 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Maues | MBZ | Brazil | 263 km | 1h 20m | AD |
| Manicore | MNX | Brazil | 337 km | 1h 30m | AD |
| Coari | CIZ | Brazil | 362 km | 1h 40m | AD |
| Parintins | PIN | Brazil | 365 km | 1h 10m | AD |
| Barbelos | BAZ | Brazil | 394 km | 1h 40m | AD |
| Trombetas | TMT | Brazil | 440 km | 1h 25m | AD |
| Itaituba | ITB | Brazil | 472 km | 1h 30m | AD |
| Tefe | TFF | Brazil | 521 km | 1h 10m | AD |
| Santarem | STM | Brazil | 588 km | 1h 15m | AD, G3 |
| Boa Vista | BVB | Brazil | 652 km | 1h 15m | AD, G3 |
| Labrea | LBR | Brazil | 707 km | 2h 45m | AD |
| Porto Velho | PVH | Brazil | 759 km | 1h 30m | AD, G3 |
| Sao Gabriel Cachoeira | SJL | Brazil | 835 km | 1h 35m | AD |
| Tabatinga | TBT | Brazil | 1,107 km | 1h 50m | AD |
| Rio Branco | RBR | Brazil | 1,151 km | 1h 55m | G3 |
| Belem | BEL | Brazil | 1,299 km | 2h 5m | LA, AD, TP |
| Bogota | BOG | Colombia | 1,785 km | 2h 55m | AV |
| Brasilia | BSB | Brazil | 1,944 km | 3h 0m | G3, LA |
| Fortaleza | FOR | Brazil | 2,391 km | 3h 25m | G3, LA |
| Panama City | PTY | Panama | 2,528 km | 3h 46m | CM |
| Belo Horizonte | CNF | Brazil | 2,535 km | 3h 35m | AD |
| Campinas | VCP | Brazil | 2,611 km | 3h 40m | AD |
| Sao Paulo | GRU | Brazil | 2,688 km | 3h 55m | G3, LA |
| Recife | REC | Brazil | 2,839 km | 3h 50m | AD |
| Rio De Janeiro | GIG | Brazil | 2,841 km | 4h 5m | G3, LA |