Del Caribe International Gen Santago Marino offers nonstop service to 28 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Barcelona | BLA | Venezuela | 119 km | 0h 35m | V0 |
| Maturin | MUN | Venezuela | 156 km | 0h 45m | V0 |
| Puerto Ordaz | PZO | Venezuela | 319 km | 0h 50m | V0 |
| Caracas | CCS | Venezuela | 334 km | 0h 45m | 5R, 9V |
| Valencia | VLN | Venezuela | 440 km | 1h 0m | T9, V0 |
| Bridgetown | BGI | Barbados | 543 km | 1h 30m | V0 |
| Barquisimeto | BRM | Venezuela | 597 km | 1h 0m | V0 |
| Valera | VLV | Venezuela | 745 km | 1h 15m | V0 |
| Maracaibo | MAR | Venezuela | 849 km | 1h 20m | V0 |
| El Vigia | VIG | Venezuela | 879 km | 1h 25m | T9, V0 |
| La Fria | LFR | Venezuela | 958 km | 1h 20m | V0 |
| Santo Domingo | STD | Venezuela | 961 km | 1h 25m | V0 |
| San Antonio del Tachira | SVZ | Venezuela | 990 km | 2h 0m | |
| Panama City | PTY | Panama | 1,702 km | 2h 44m | CM |