Hato offers nonstop service to 46 destinations, served by 25 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bonaire | BON | Caribbean Netherlands | 74 km | 0h 30m | 3R, 7Z, OR, WM |
| Aruba | AUA | Aruba | 119 km | 0h 30m | 3R, 7Z, AR, OR, WM |
| Caracas | CCS | Venezuela | 276 km | 1h 0m | 9V, G6, QL |
| Barranquilla | BAQ | Colombia | 651 km | 2h 0m | 7Z |
| Santo Domingo | SDQ | Dominican Republic | 694 km | 1h 20m | DM, L5 |
| Santo Domingo | JBQ | Dominican Republic | 714 km | 1h 0m | Y2 |
| Port Of Spain | POS | Trinidad and Tobago | 849 km | 1h 40m | BW |
| Sint Maarten | SXM | Sint Maarten | 902 km | 2h 25m | 7Z, WM |
| Medellin | MDE | Colombia | 973 km | 1h 55m | 7Z, P5 |
| Bogota | BOG | Colombia | 1,005 km | 1h 55m | AV, P5 |
| Panama City | PTY | Panama | 1,191 km | 2h 16m | CM |
| Paramaribo | PBM | Suriname | 1,687 km | 2h 30m | PY |
| Miami | MIA | USA | 1,918 km | 3h 19m | AA |
| Charlotte | CLT | USA | 2,822 km | 4h 32m | AA |
| Atlanta | ATL | USA | 2,849 km | 4h 25m | DL |
| New York | JFK | USA | 3,188 km | 4h 52m | B6 |
| New York | EWR | USA | 3,199 km | 5h 0m | UA |
| Toronto | YYZ | Canada | 3,637 km | 5h 35m | AC, WS |
| Montreal | YUL | Canada | 3,715 km | 5h 20m | AC |
| Chicago | ORD | USA | 3,778 km | 5h 55m | AA |
| Belo Horizonte | CNF | Brazil | 4,460 km | 6h 0m | AD |
| Buenos Aires | EZE | Argentina | 5,316 km | 7h 10m | AR |
| Amsterdam | AMS | Netherlands | 7,838 km | 9h 15m | CD, KL, OR |