Jose Marti International offers nonstop service to 30 destinations, served by 24 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Nueva Gerona | GER | Cuba | 134 km | 0h 35m | CU |
| Miami | MIA | USA | 377 km | 1h 16m | AA, DL |
| Grand Cayman Island | GCM | Cayman Islands | 424 km | 1h 15m | KX |
| Cancun | CUN | Mexico | 509 km | 1h 25m | AM, VB, TK |
| Tampa | TPA | USA | 551 km | 1h 25m | WN |
| Nassau | NAS | Bahamas | 551 km | 1h 15m | UP, AF, CA |
| Santiago | SCU | Cuba | 759 km | 1h 25m | CU |
| Merida | MID | Mexico | 783 km | 1h 40m | VB |
| Guantanamo | GAO | Cuba | 817 km | 2h 20m | CU |
| Providenciales | PLS | Turks and Caicos Islands | 1,053 km | 1h 45m | JY |
| Managua | MGA | Nicaragua | 1,265 km | 2h 30m | V0 |
| Santo Domingo | JBQ | Dominican Republic | 1,382 km | 1h 30m | Y2 |
| Santo Domingo | SDQ | Dominican Republic | 1,418 km | 2h 0m | DO, 2W, UX, IB |
| Punta Cana | PUJ | Dominican Republic | 1,541 km | 2h 5m | DO, NO |
| Panama City | PTY | Panama | 1,575 km | 2h 41m | CM |
| Balboa | BLB | Panama | 1,587 km | 2h 33m | P5 |
| Mexico City | NLU | Mexico | 1,758 km | 3h 0m | VB |
| Monterrey | MTY | Mexico | 1,820 km | 3h 15m | VB |
| Caracas | CCS | Venezuela | 2,136 km | 3h 30m | V0 |
| Bogota | BOG | Colombia | 2,211 km | 3h 17m | P5 |
| Toronto | YYZ | Canada | 2,308 km | 3h 43m | WS |
| Port Of Spain | POS | Trinidad and Tobago | 2,626 km | 3h 50m | BW |
| Georgetown | GEO | Guyana | 3,167 km | 2h 50m | DO |
| Buenos Aires | EZE | Argentina | 6,877 km | 8h 30m | CU |
| Madrid | MAD | Spain | 7,473 km | 8h 55m | CU, IB, UX, 2W, CA |
| Paris | CDG | France | 7,757 km | 9h 15m | AF |
| Milan | MXP | Italy | 8,301 km | 9h 40m | NO |
| Rome | FCO | Italy | 8,709 km | 9h 50m | NO |
| Istanbul | IST | Turkiye | 9,974 km | 11h 40m | TK |
| Luanda | NBJ | Angola | 11,005 km | 13h 45m | DT |