Jose Marti International offers nonstop service to 54 destinations, served by 19 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Nueva Gerona | GER | Cuba | 134 km | 0h 35m | CU |
| Miami | MIA | USA | 377 km | 1h 17m | AA, DL |
| Cancun | CUN | Mexico | 509 km | 1h 25m | VB |
| Nassau | NAS | Bahamas | 551 km | 1h 15m | CA, UP |
| Tampa | TPA | USA | 551 km | 1h 25m | WN |
| Montego Bay | MBJ | Jamaica | 683 km | 1h 28m | P5 |
| Santiago | SCU | Cuba | 759 km | 1h 25m | CU |
| Merida | MID | Mexico | 783 km | 1h 44m | VB |
| Guantanamo | GAO | Cuba | 817 km | 2h 20m | CU |
| Providenciales | PLS | Turks and Caicos Islands | 1,053 km | 1h 45m | JY |
| Santo Domingo | JBQ | Dominican Republic | 1,382 km | 2h 0m | Y2 |
| Santo Domingo | SDQ | Dominican Republic | 1,418 km | 2h 20m | DO |
| La Romana | LRM | Dominican Republic | 1,494 km | 2h 0m | NO |
| Punta Cana | PUJ | Dominican Republic | 1,541 km | 2h 15m | DO, NO, UX, Y2 |
| Panama City | PTY | Panama | 1,575 km | 2h 42m | CM |
| Balboa | BLB | Panama | 1,587 km | 2h 33m | P5 |
| Mexico City | NLU | Mexico | 1,758 km | 3h 0m | VB |
| Mexico City | MEX | Mexico | 1,773 km | 3h 10m | AM |
| Monterrey | MTY | Mexico | 1,820 km | 3h 15m | VB |
| Valencia | VLN | Venezuela | 2,096 km | 3h 0m | V0 |
| Bogota | BOG | Colombia | 2,211 km | 3h 19m | P5 |
| Port Of Spain | POS | Trinidad and Tobago | 2,626 km | 3h 50m | BW |
| Buenos Aires | EZE | Argentina | 6,877 km | 9h 0m | CU |
| Madrid | MAD | Spain | 7,473 km | 8h 48m | CA, CU, IB, UX |
| Milan | MXP | Italy | 8,301 km | 9h 45m | NO |
| Rome | FCO | Italy | 8,709 km | 9h 35m | NO |
| Istanbul | IST | Turkiye | 9,974 km | 11h 40m | TK |