Managua International offers nonstop service to 22 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bluefields | BEF | Nicaragua | 261 km | 1h 0m | LC |
| San Jose | SJO | Costa Rica | 320 km | 1h 3m | CM, RZ |
| Corn Island | RNI | Nicaragua | 338 km | 1h 25m | LC |
| San Salvador | SAL | El Salvador | 344 km | 0h 55m | AV |
| Puerto Cabezas | PUZ | Nicaragua | 368 km | 1h 15m | LC |
| Guatemala City | GUA | Guatemala | 544 km | 1h 15m | CM |
| Panama City | PTY | Panama | 816 km | 1h 42m | CM |
| Mexico City | MEX | Mexico | 1,599 km | 2h 45m | AM |
| Miami | MIA | USA | 1,632 km | 2h 35m | AA, AV |
| Houston | IAH | USA | 2,190 km | 3h 26m | UA |
| Montreal | YUL | Canada | 3,876 km | 5h 20m | WS |