Reina Beatrix International offers nonstop service to 72 destinations, served by 24 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Curacao | CUR | Curaçao | 119 km | 0h 35m | 3R, 7Z, AR, DM, OR, PY, WM |
| Bonaire | BON | Caribbean Netherlands | 193 km | 0h 50m | 7Z, KL, OR |
| Barranquilla | BAQ | Colombia | 549 km | 1h 15m | P5 |
| Santo Domingo | JBQ | Dominican Republic | 671 km | 1h 0m | Y2 |
| Bucaramanga | BGA | Colombia | 688 km | 1h 29m | P5 |
| Punta Cana | PUJ | Dominican Republic | 693 km | 1h 20m | DM |
| Medellin | MDE | Colombia | 918 km | 1h 46m | P5 |
| Bogota | BOG | Colombia | 975 km | 1h 50m | AV, P5 |
| Panama City | PTY | Panama | 1,093 km | 2h 13m | CM |
| Cali | CLO | Colombia | 1,213 km | 2h 8m | P5 |
| Miami | MIA | USA | 1,823 km | 3h 14m | AA |
| Fort Lauderdale | FLL | USA | 1,839 km | 3h 4m | B6 |
| Orlando | MCO | USA | 2,118 km | 3h 20m | WN |
| Charlotte | CLT | USA | 2,746 km | 4h 25m | AA |
| Atlanta | ATL | USA | 2,761 km | 4h 20m | DL |
| Lima | LIM | Peru | 2,823 km | 4h 20m | LA |
| Dulles | IAD | USA | 3,021 km | 4h 36m | UA |
| Baltimore | BWI | USA | 3,027 km | 4h 30m | WN |
| Philadelphia | PHL | USA | 3,076 km | 4h 44m | AA |
| Nashville | BNA | USA | 3,104 km | 4h 45m | WN |
| New York | JFK | USA | 3,140 km | 4h 48m | B6, DL |
| New York | EWR | USA | 3,149 km | 5h 1m | UA |
| New York | LGA | USA | 3,155 km | 4h 56m | AA |
| Houston | IAH | USA | 3,250 km | 5h 3m | UA |
| Boston | BOS | USA | 3,311 km | 5h 1m | B6, DL |
| Detroit | DTW | USA | 3,536 km | 5h 30m | DL |
| Dallas | DFW | USA | 3,558 km | 5h 39m | AA |
| Toronto | YYZ | Canada | 3,576 km | 5h 30m | AC, PD, WS |
| Montreal | YUL | Canada | 3,670 km | 5h 15m | AC, TS |
| Ottawa | YOW | Canada | 3,677 km | 5h 45m | PD |
| Chicago | ORD | USA | 3,698 km | 5h 58m | AA, UA |
| Minneapolis | MSP | USA | 4,212 km | 6h 19m | DL, SY |
| Sao Paulo | GRU | Brazil | 4,729 km | 6h 20m | G3 |
| Buenos Aires | EZE | Argentina | 5,374 km | 7h 15m | AR |
| Amsterdam | AMS | Netherlands | 7,882 km | 9h 55m | OR |