Alfonso Bonilla Aragon International offers nonstop service to 56 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Guapi | GPI | Colombia | 200 km | 0h 50m | 9R, VE |
| Florencia | FLA | Colombia | 234 km | 1h 9m | 9R |
| Quibdo | UIB | Colombia | 239 km | 1h 0m | VE |
| Pasto | PSO | Colombia | 249 km | 1h 0m | AV, VE |
| Bogota | BOG | Colombia | 279 km | 1h 5m | AV, JA, LA, P5, VE |
| Medellin | EOH | Colombia | 308 km | 1h 5m | VE |
| Medellin | MDE | Colombia | 309 km | 0h 55m | AV, JA, LA |
| Villavicencio | VVC | Colombia | 315 km | 1h 15m | VE |
| Tumaco | TCO | Colombia | 326 km | 1h 15m | 9R, VE |
| Ipiales | IPI | Colombia | 329 km | 1h 8m | 9R |
| Puerto Asis | PUU | Colombia | 333 km | 1h 10m | 9R, VE |
| Balboa | BLB | Panama | 692 km | 1h 22m | P5 |
| Panama City | PTY | Panama | 695 km | 1h 40m | CM |
| Cartagena | CTG | Colombia | 769 km | 1h 30m | AV, JA, LA |
| Barranquilla | BAQ | Colombia | 831 km | 1h 30m | AV |
| Santa Marta | SMR | Colombia | 870 km | 1h 36m | AV, JA |
| San Andres Island | ADZ | Colombia | 1,159 km | 1h 55m | AV, JA, LA |
| Aruba | AUA | Aruba | 1,213 km | 2h 4m | P5 |
| Punta Cana | PUJ | Dominican Republic | 1,876 km | 2h 57m | JA |
| Miami | MIA | USA | 2,497 km | 4h 2m | AA, AV |
| Fort Lauderdale | FLL | USA | 2,525 km | 3h 55m | AV, B6 |
| Mexico City | MEX | Mexico | 3,028 km | 4h 38m | AM |
| Antofagasta | ANF | Chile | 3,054 km | 4h 25m | JA |
| Santiago | SCL | Chile | 4,130 km | 5h 42m | JA |
| Madrid | MAD | Spain | 8,305 km | 9h 45m | 2W, AV |