Cibao International offers nonstop service to 22 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Providenciales | PLS | Turks and Caicos Islands | 314 km | 1h 10m | 9Q, JY |
| San Juan | SJU | Puerto Rico | 495 km | 1h 11m | B6 |
| Miami | MIA | USA | 1,220 km | 2h 23m | AA |
| Fort Lauderdale | FLL | USA | 1,226 km | 2h 16m | B6 |
| Orlando | MCO | USA | 1,477 km | 2h 39m | B6 |
| Panama City | PTY | Panama | 1,484 km | 2h 47m | CM |
| Philadelphia | PHL | USA | 2,312 km | 3h 48m | AA, F9 |
| New York | JFK | USA | 2,374 km | 3h 50m | B6, DL |
| New York | EWR | USA | 2,384 km | 3h 58m | B6, UA |
| Boston | BOS | USA | 2,546 km | 4h 0m | B6 |
| Madrid | MAD | Spain | 6,713 km | 8h 15m | UX |