Sarasota Bradenton International Airport offers nonstop service to 68 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Orlando | MCO | USA | 168 km | 0h 55m | WN |
| Miami | MIA | USA | 287 km | 1h 4m | AA |
| Atlanta | ATL | USA | 716 km | 1h 44m | DL |
| Greenville | GSP | USA | 832 km | 1h 34m | G4 |
| Charlotte | CLT | USA | 881 km | 2h 1m | AA |
| Asheville | AVL | USA | 892 km | 1h 43m | G4 |
| Knoxville | TYS | USA | 943 km | 1h 46m | G4 |
| Raleigh/Durham | RDU | USA | 1,006 km | 2h 3m | MX |
| Nashville | BNA | USA | 1,044 km | 2h 0m | G4, WN |
| Roanoke | ROA | USA | 1,127 km | 2h 9m | G4 |
| Lexington | LEX | USA | 1,196 km | 2h 4m | G4 |
| Richmond | RIC | USA | 1,224 km | 2h 13m | MX |
| Louisville | SDF | USA | 1,232 km | 2h 10m | G4 |
| Houston | HOU | USA | 1,269 km | 2h 20m | WN |
| Houston | IAH | USA | 1,281 km | 2h 51m | UA |
| Cincinnati | CVG | USA | 1,308 km | 2h 19m | G4 |
| Dulles | IAD | USA | 1,367 km | 2h 21m | G4 |
| Washington | DCA | USA | 1,370 km | 2h 32m | AA |
| Columbus | LCK | USA | 1,379 km | 2h 19m | G4 |
| Columbus | CMH | USA | 1,399 km | 2h 25m | WN |
| Indianapolis | IND | USA | 1,410 km | 2h 25m | G4, WN |
| Belleville | BLV | USA | 1,410 km | 2h 26m | G4 |
| Baltimore | BWI | USA | 1,417 km | 2h 25m | WN |
| Saint Louis | STL | USA | 1,455 km | 2h 30m | WN |
| Pittsburgh | PIT | USA | 1,469 km | 2h 25m | G4, WN |
| Dallas | DAL | USA | 1,502 km | 2h 50m | WN |
| Akron | CAK | USA | 1,504 km | 2h 28m | G4, MX |
| Austin | AUS | USA | 1,506 km | 2h 28m | G4 |
| Wilmington | ILG | USA | 1,506 km | 2h 35m | XP |
| Middletown | MDT | USA | 1,517 km | 2h 30m | G4 |
| Dallas | DFW | USA | 1,521 km | 3h 0m | AA |
| Fort Wayne | FWA | USA | 1,527 km | 2h 30m | G4 |
| Philadelphia | PHL | USA | 1,540 km | 2h 47m | F9, AA |
| Cleveland | CLE | USA | 1,557 km | 2h 46m | F9, WN |
| Toledo | TOL | USA | 1,579 km | 2h 30m | G4 |
| Allentown | ABE | USA | 1,610 km | 2h 41m | G4 |
| Peoria | PIA | USA | 1,612 km | 2h 35m | G4 |
| South Bend | SBN | USA | 1,624 km | 2h 38m | G4 |
| Detroit | DTW | USA | 1,645 km | 2h 49m | DL |
| New York | EWR | USA | 1,663 km | 2h 53m | UA |
| Chicago | MDW | USA | 1,666 km | 2h 45m | WN |
| New York | JFK | USA | 1,676 km | 2h 51m | B6, DL |
| New York | LGA | USA | 1,685 km | 2h 51m | DL |
| Chicago | ORD | USA | 1,690 km | 3h 13m | UA, AA |
| Westchester County | HPN | USA | 1,720 km | 2h 54m | MX |
| Moline | MLI | USA | 1,721 km | 3h 1m | G4 |
| Islip | ISP | USA | 1,721 km | 2h 51m | MX |
| Flint | FNT | USA | 1,732 km | 2h 53m | G4 |
| Kansas City | MCI | USA | 1,736 km | 2h 50m | WN |
| Grand Rapids | GRR | USA | 1,740 km | 2h 49m | G4 |
| Rockford | RFD | USA | 1,747 km | 2h 53m | G4 |
| Buffalo | BUF | USA | 1,759 km | 2h 50m | WN |
| New Haven | HVN | USA | 1,775 km | 2h 52m | XP |
| Milwaukee | MKE | USA | 1,792 km | 2h 55m | WN |
| Rochester | ROC | USA | 1,801 km | 2h 48m | G4 |
| Cedar Rapids | CID | USA | 1,811 km | 3h 5m | G4 |
| Toronto | YYZ | Canada | 1,827 km | 2h 58m | AC |
| Syracuse | SYR | USA | 1,839 km | 2h 56m | G4 |
| Hartford | BDL | USA | 1,846 km | 3h 0m | MX |
| Des Moines | DSM | USA | 1,867 km | 2h 58m | G4 |
| Albany | ALB | USA | 1,878 km | 2h 55m | G4 |
| Providence | PVD | USA | 1,885 km | 3h 1m | MX |
| Appleton | ATW | USA | 1,946 km | 3h 7m | G4 |
| Boston | BOS | USA | 1,963 km | 3h 9m | B6, DL, G4 |
| Omaha | OMA | USA | 1,967 km | 3h 6m | G4 |
| Portland | PWM | USA | 2,113 km | 3h 14m | MX |
| Minneapolis | MSP | USA | 2,160 km | 3h 37m | DL, SY |
| Denver | DEN | USA | 2,463 km | 4h 11m | UA, WN |