Kansas City International Airport offers nonstop service to 110 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Saint Louis | STL | USA | 380 km | 1h 5m | WN |
| Minneapolis | MSP | USA | 633 km | 1h 34m | DL |
| Chicago | ORD | USA | 648 km | 1h 49m | AA, UA |
| Chicago | MDW | USA | 652 km | 1h 25m | WN |
| Milwaukee | MKE | USA | 701 km | 1h 30m | WN |
| Indianapolis | IND | USA | 726 km | 1h 25m | WN |
| Dallas | DFW | USA | 739 km | 1h 52m | AA |
| Dallas | DAL | USA | 740 km | 1h 35m | WN |
| Nashville | BNA | USA | 791 km | 1h 35m | WN |
| Denver | DEN | USA | 857 km | 1h 50m | AA, F9, UA, WN |
| Detroit | DTW | USA | 1,011 km | 1h 55m | DL |
| Columbus | CMH | USA | 1,018 km | 1h 50m | WN |
| Houston | IAH | USA | 1,034 km | 2h 17m | UA |
| Austin | AUS | USA | 1,043 km | 2h 0m | DL, WN |
| Houston | HOU | USA | 1,071 km | 2h 5m | WN |
| New Orleans | MSY | USA | 1,110 km | 1h 55m | WN |
| Atlanta | ATL | USA | 1,113 km | 2h 1m | DL, F9, WN |
| San Antonio | SAT | USA | 1,136 km | 2h 5m | WN |
| Albuquerque | ABQ | USA | 1,155 km | 2h 10m | WN |
| Gulf Shores | GUF | USA | 1,188 km | 2h 2m | G4 |
| Pensacola | PNS | USA | 1,194 km | 2h 0m | WN |
| Fort Walton Beach | VPS | USA | 1,227 km | 2h 7m | G4, WN |
| Panama City | ECP | USA | 1,282 km | 2h 5m | WN |
| Charlotte | CLT | USA | 1,302 km | 2h 22m | AA |
| Raleigh/Durham | RDU | USA | 1,455 km | 2h 27m | DL, WN |
| Savannah | SAV | USA | 1,455 km | 2h 20m | WN |
| Salt Lake City | SLC | USA | 1,479 km | 2h 45m | DL |
| Dulles | IAD | USA | 1,491 km | 2h 27m | UA |
| Washington | DCA | USA | 1,528 km | 2h 20m | AA, WN |
| Baltimore | BWI | USA | 1,555 km | 2h 20m | WN |
| Philadelphia | PHL | USA | 1,671 km | 2h 48m | AA |
| Phoenix | PHX | USA | 1,678 km | 2h 55m | AA, WN |
| Saint Petersburg | PIE | USA | 1,681 km | 2h 35m | G4 |
| Tampa | TPA | USA | 1,685 km | 2h 35m | WN |
| Orlando | MCO | USA | 1,725 km | 2h 40m | DL, F9, WN |
| Sarasota | SRQ | USA | 1,736 km | 2h 40m | WN |
| New York | EWR | USA | 1,757 km | 2h 58m | UA |
| New York | LGA | USA | 1,782 km | 2h 40m | DL, WN |
| New York | JFK | USA | 1,790 km | 2h 54m | DL |
| Punta Gorda | PGD | USA | 1,811 km | 2h 49m | G4 |
| Las Vegas | LAS | USA | 1,832 km | 3h 5m | F9, WN |
| Fort Myers | RSW | USA | 1,860 km | 2h 45m | WN |
| Fort Lauderdale | FLL | USA | 1,999 km | 2h 55m | G4, WN |
| Miami | MIA | USA | 2,014 km | 3h 11m | AA, WN |
| Boston | BOS | USA | 2,021 km | 2h 59m | AA, DL, WN |
| San Diego | SAN | USA | 2,146 km | 3h 30m | WN |
| Cancun | CUN | Mexico | 2,157 km | 3h 20m | AA, DL, WN |
| Los Angeles | LAX | USA | 2,193 km | 3h 39m | DL, UA, WN |
| San Jose Cabo | SJD | Mexico | 2,282 km | 3h 45m | WN |
| Sacramento | SMF | USA | 2,320 km | 3h 45m | WN |
| Portland | PDX | USA | 2,383 km | 3h 55m | AS, WN |
| Seattle | SEA | USA | 2,395 km | 4h 1m | AS, DL, WN |
| San Francisco | SFO | USA | 2,412 km | 4h 10m | AA, UA, WN |
| Montego Bay | MBJ | Jamaica | 2,817 km | 3h 55m | WN |
| Punta Cana | PUJ | Dominican Republic | 3,423 km | 4h 40m | WN |