Syracuse Hancock International offers nonstop service to 28 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| New York | EWR | USA | 313 km | 1h 20m | UA |
| New York | LGA | USA | 319 km | 1h 18m | DL |
| New York | JFK | USA | 335 km | 1h 24m | B6, DL |
| Philadelphia | PHL | USA | 366 km | 1h 19m | AA |
| Boston | BOS | USA | 425 km | 1h 15m | AA, B6 |
| Dulles | IAD | USA | 475 km | 1h 28m | UA |
| Washington | DCA | USA | 479 km | 1h 32m | AA |
| Detroit | DTW | USA | 602 km | 1h 36m | DL |
| Raleigh/Durham | RDU | USA | 836 km | 1h 54m | MX |
| Charlotte | CLT | USA | 970 km | 2h 14m | AA |
| Chicago | ORD | USA | 976 km | 2h 19m | AA, UA |
| Myrtle Beach | MYR | USA | 1,075 km | 1h 59m | G4 |
| Charleston | CHS | USA | 1,186 km | 2h 20m | MX |
| Nashville | BNA | USA | 1,191 km | 2h 7m | G4 |
| Atlanta | ATL | USA | 1,277 km | 2h 28m | DL |
| Minneapolis | MSP | USA | 1,382 km | 2h 32m | DL, SY |
| Orlando | SFB | USA | 1,656 km | 2h 42m | G4 |
| Orlando | MCO | USA | 1,694 km | 3h 1m | B6, F9 |
| Tampa | TPA | USA | 1,775 km | 3h 9m | MX |
| Saint Petersburg | PIE | USA | 1,787 km | 2h 54m | G4 |
| Sarasota | SRQ | USA | 1,839 km | 2h 58m | G4 |
| Punta Gorda | PGD | USA | 1,873 km | 3h 0m | G4 |
| Fort Myers | RSW | USA | 1,909 km | 3h 22m | MX |
| Fort Lauderdale | FLL | USA | 1,925 km | 3h 9m | B6, G4 |
| Miami | MIA | USA | 1,958 km | 3h 33m | AA |
| Dallas | DFW | USA | 2,150 km | 3h 49m | AA |
| Denver | DEN | USA | 2,400 km | 3h 53m | UA |
| Las Vegas | LAS | USA | 3,409 km | 5h 44m | MX |