Indianapolis International Airport offers nonstop service to 56 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | MDW | USA | 260 km | 1h 0m | WN |
| Chicago | ORD | USA | 285 km | 1h 22m | AA, UA |
| Saint Louis | STL | USA | 368 km | 1h 0m | WN |
| Detroit | DTW | USA | 371 km | 1h 13m | DL |
| Nashville | BNA | USA | 399 km | 1h 10m | WN |
| Charlotte | CLT | USA | 687 km | 1h 46m | AA |
| Atlanta | ATL | USA | 694 km | 1h 39m | DL, WN, F9 |
| Toronto | YYZ | Canada | 709 km | 1h 34m | AC |
| Kansas City | MCI | USA | 726 km | 1h 30m | WN |
| Dulles | IAD | USA | 766 km | 1h 44m | UA |
| Raleigh/Durham | RDU | USA | 786 km | 1h 43m | DL |
| Washington | DCA | USA | 803 km | 1h 46m | AA |
| Minneapolis | MSP | USA | 808 km | 1h 50m | DL, SY |
| Baltimore | BWI | USA | 830 km | 1h 35m | WN |
| Lincoln | LNK | USA | 897 km | 1h 50m | AA |
| Myrtle Beach | MYR | USA | 938 km | 1h 46m | G4 |
| Charleston | CHS | USA | 943 km | 1h 49m | G4 |
| Philadelphia | PHL | USA | 945 km | 1h 56m | AA |
| Savannah | SAV | USA | 957 km | 1h 46m | G4 |
| Fort Walton Beach | VPS | USA | 1,023 km | 1h 51m | G4 |
| New York | EWR | USA | 1,036 km | 2h 7m | UA, NK |
| Panama City | ECP | USA | 1,039 km | 1h 50m | WN |
| New York | LGA | USA | 1,062 km | 2h 7m | AA, DL |
| New York | JFK | USA | 1,069 km | 2h 14m | AA, DL |
| Jacksonville | JAX | USA | 1,105 km | 2h 1m | G4 |
| Dallas | DAL | USA | 1,215 km | 2h 20m | WN |
| Dallas | DFW | USA | 1,224 km | 2h 34m | AA, F9 |
| Orlando | SFB | USA | 1,299 km | 2h 14m | G4 |
| Boston | BOS | USA | 1,315 km | 2h 23m | DL, AA, G4 |
| Orlando | MCO | USA | 1,332 km | 2h 20m | DL, F9, WN, NK |
| Tampa | TPA | USA | 1,347 km | 2h 15m | WN |
| Saint Petersburg | PIE | USA | 1,350 km | 2h 16m | G4 |
| Houston | IAH | USA | 1,358 km | 2h 37m | UA |
| Houston | HOU | USA | 1,386 km | 2h 30m | WN |
| Sarasota | SRQ | USA | 1,410 km | 2h 20m | G4, WN |
| Punta Gorda | PGD | USA | 1,474 km | 2h 31m | G4 |
| Austin | AUS | USA | 1,478 km | 2h 40m | WN, DL |
| Fort Myers | RSW | USA | 1,522 km | 2h 25m | F9, WN |
| Denver | DEN | USA | 1,571 km | 2h 50m | F9, UA, WN |
| Fort Lauderdale | FLL | USA | 1,617 km | 2h 39m | G4, WN, NK, F9 |
| Miami | MIA | USA | 1,642 km | 2h 49m | AA, WN |
| Key West | EYW | USA | 1,734 km | 2h 42m | G4 |
| Cancun | CUN | Mexico | 2,071 km | 3h 35m | DL, WN, AA |
| Salt Lake City | SLC | USA | 2,180 km | 3h 52m | DL |
| Phoenix | PHX | USA | 2,394 km | 3h 55m | AA, WN, F9 |
| Las Vegas | LAS | USA | 2,558 km | 4h 0m | F9, G4, WN, NK |
| San Diego | SAN | USA | 2,868 km | 4h 15m | WN |
| San Jose Cabo | SJD | Mexico | 2,869 km | 4h 40m | WN |
| Burbank | BUR | USA | 2,904 km | 4h 19m | G4 |
| Punta Cana | PUJ | Dominican Republic | 2,910 km | 4h 10m | AA |
| Los Angeles | LAX | USA | 2,919 km | 4h 40m | AA, DL |
| Seattle | SEA | USA | 3,002 km | 4h 50m | AS, AA |
| Portland | PDX | USA | 3,019 km | 4h 39m | G4 |
| San Juan | SJU | Puerto Rico | 3,060 km | 4h 20m | WN |
| San Francisco | SFO | USA | 3,129 km | 4h 57m | UA |
| Dublin | DUB | Ireland | 5,984 km | 7h 45m | EI |