Asheville Regional Airport offers nonstop service to 26 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Charlotte | CLT | USA | 147 km | 1h 13m | AA |
| Atlanta | ATL | USA | 265 km | 1h 8m | DL |
| Dulles | IAD | USA | 597 km | 1h 29m | G4 |
| Washington | DCA | USA | 617 km | 1h 37m | AA |
| Fort Walton Beach | VPS | USA | 663 km | 1h 28m | G4 |
| Orlando | SFB | USA | 748 km | 1h 30m | G4 |
| Orlando | MCO | USA | 785 km | 1h 39m | G4 |
| Philadelphia | PHL | USA | 810 km | 1h 52m | AA |
| Saint Petersburg | PIE | USA | 834 km | 1h 38m | G4 |
| Chicago | MDW | USA | 837 km | 1h 44m | G4 |
| Chicago | ORD | USA | 862 km | 2h 11m | UA, AA |
| Sarasota | SRQ | USA | 892 km | 1h 42m | G4 |
| New York | EWR | USA | 936 km | 2h 4m | G4, UA |
| Punta Gorda | PGD | USA | 945 km | 1h 50m | G4 |
| New York | LGA | USA | 962 km | 1h 58m | DL, AA |
| West Palm Beach | PBI | USA | 997 km | 1h 50m | G4 |
| Fort Lauderdale | FLL | USA | 1,062 km | 1h 58m | G4 |
| Miami | MIA | USA | 1,090 km | 2h 4m | AA |
| Key West | EYW | USA | 1,208 km | 2h 6m | G4 |
| Boston | BOS | USA | 1,259 km | 2h 13m | G4, B6, DL |
| Houston | HOU | USA | 1,356 km | 2h 28m | G4 |
| Dallas | DFW | USA | 1,364 km | 2h 43m | AA |
| Minneapolis | MSP | USA | 1,385 km | 2h 30m | DL, SY |
| Austin | AUS | USA | 1,528 km | 2h 46m | G4, DL |
| Denver | DEN | USA | 2,008 km | 3h 23m | G4, UA |
| Las Vegas | LAS | USA | 2,936 km | 4h 28m | G4 |