Akron Canton Regional Airport offers nonstop service to 44 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Washington | DCA | USA | 439 km | 1h 30m | AA |
| Chicago | ORD | USA | 553 km | 1h 56m | AA, UA |
| Raleigh/Durham | RDU | USA | 605 km | 1h 28m | MX |
| Charlotte | CLT | USA | 633 km | 1h 52m | AA |
| Wilmington | ILM | USA | 800 km | 1h 36m | MX |
| Myrtle Beach | MYR | USA | 832 km | 1h 37m | G4, MX |
| Charleston | CHS | USA | 899 km | 1h 48m | MX |
| Portland | PWM | USA | 965 km | 1h 52m | MX |
| Savannah | SAV | USA | 974 km | 1h 50m | G4, MX |
| Jacksonville | JAX | USA | 1,156 km | 2h 7m | G4, MX |
| Fort Walton Beach | VPS | USA | 1,244 km | 2h 10m | G4 |
| Daytona Beach | DAB | USA | 1,301 km | 2h 30m | MX |
| Orlando | SFB | USA | 1,346 km | 2h 17m | G4 |
| Orlando | MCO | USA | 1,384 km | 2h 33m | MX |
| Tampa | TPA | USA | 1,438 km | 2h 32m | MX |
| Saint Petersburg | PIE | USA | 1,447 km | 2h 24m | G4 |
| Sarasota | SRQ | USA | 1,504 km | 2h 35m | G4, MX |
| Punta Gorda | PGD | USA | 1,553 km | 2h 36m | G4 |
| West Palm Beach | DJT | USA | 1,583 km | 2h 47m | MX |
| Fort Myers | RSW | USA | 1,596 km | 2h 50m | MX |
| Fort Lauderdale | FLL | USA | 1,650 km | 2h 53m | G4, MX |
| Las Vegas | LAS | USA | 2,970 km | 5h 0m | MX |