Eppley Afld offers nonstop service to 37 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Minneapolis | MSP | USA | 454 km | 1h 20m | DL |
| Saint Louis | STL | USA | 549 km | 1h 15m | WN |
| Chicago | ORD | USA | 670 km | 1h 50m | AA, UA |
| Chicago | MDW | USA | 682 km | 1h 25m | WN |
| Denver | DEN | USA | 759 km | 1h 47m | F9, UA, WN |
| Dallas | DFW | USA | 937 km | 2h 2m | AA |
| Dallas | DAL | USA | 942 km | 1h 50m | WN |
| Nashville | BNA | USA | 985 km | 1h 45m | WN |
| Detroit | DTW | USA | 1,047 km | 2h 0m | DL |
| Austin | AUS | USA | 1,241 km | 2h 20m | WN |
| Houston | IAH | USA | 1,256 km | 2h 24m | UA |
| Houston | HOU | USA | 1,294 km | 2h 20m | WN |
| Atlanta | ATL | USA | 1,320 km | 2h 18m | DL, F9 |
| Salt Lake City | SLC | USA | 1,351 km | 2h 43m | DL |
| Gulf Shores | GUF | USA | 1,428 km | 2h 16m | G4 |
| Fort Walton Beach | VPS | USA | 1,464 km | 2h 28m | G4 |
| Charlotte | CLT | USA | 1,470 km | 2h 38m | AA |
| Washington | DCA | USA | 1,627 km | 2h 30m | DL, WN |
| Mesa | AZA | USA | 1,650 km | 2h 44m | G4 |
| Phoenix | PHX | USA | 1,667 km | 2h 50m | AA, WN, F9 |
| Philadelphia | PHL | USA | 1,751 km | 2h 55m | AA |
| Las Vegas | LAS | USA | 1,767 km | 2h 55m | G4, WN |
| New York | EWR | USA | 1,824 km | 2h 58m | UA |
| New York | LGA | USA | 1,848 km | 2h 51m | DL, AA, WN |
| Saint Petersburg | PIE | USA | 1,911 km | 2h 46m | G4 |
| Tampa | TPA | USA | 1,914 km | 2h 50m | WN |
| Orlando | SFB | USA | 1,923 km | 2h 52m | G4 |
| Orlando | MCO | USA | 1,948 km | 3h 0m | F9, WN |
| Sarasota | SRQ | USA | 1,967 km | 2h 50m | G4 |
| Punta Gorda | PGD | USA | 2,041 km | 3h 6m | G4 |
| San Diego | SAN | USA | 2,112 km | 3h 13m | WN |
| Los Angeles | LAX | USA | 2,140 km | 3h 45m | AA |
| Seattle | SEA | USA | 2,199 km | 3h 45m | AS |
| Fort Lauderdale | FLL | USA | 2,225 km | 3h 20m | WN |
| Miami | MIA | USA | 2,242 km | 3h 30m | AA, WN |
| Eugene | EUG | USA | 2,248 km | 3h 30m | AA |
| San Francisco | SFO | USA | 2,306 km | 3h 50m | UA |