Cleveland Hopkins International offers nonstop service to 88 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Detroit | DTW | USA | 154 km | 0h 59m | DL |
| Toronto | YYZ | Canada | 311 km | 1h 10m | AC |
| Dulles | IAD | USA | 462 km | 1h 21m | UA |
| Chicago | MDW | USA | 493 km | 1h 25m | WN |
| Washington | DCA | USA | 497 km | 1h 32m | AA |
| Baltimore | BWI | USA | 504 km | 1h 20m | WN |
| Chicago | ORD | USA | 508 km | 1h 45m | AA, UA |
| Philadelphia | PHL | USA | 583 km | 1h 33m | AA |
| New York | EWR | USA | 648 km | 1h 37m | UA |
| Raleigh/Durham | RDU | USA | 669 km | 1h 33m | F9 |
| New York | LGA | USA | 672 km | 1h 43m | AA, DL |
| Concord | USA | USA | 676 km | 1h 30m | XP |
| New York | JFK | USA | 682 km | 1h 47m | AA, B6, DL |
| Charlotte | CLT | USA | 691 km | 1h 46m | AA |
| Nashville | BNA | USA | 720 km | 1h 40m | WN |
| New Haven | HVN | USA | 748 km | 1h 29m | XP |
| Saint Louis | STL | USA | 785 km | 1h 45m | WN |
| Montreal | YUL | Canada | 793 km | 1h 38m | AC |
| Cedar Rapids | CID | USA | 822 km | 1h 57m | AA |
| Atlanta | ATL | USA | 892 km | 1h 57m | DL, F9 |
| Boston | BOS | USA | 903 km | 1h 52m | B6, DL |
| Minneapolis | MSP | USA | 1,001 km | 2h 10m | DL |
| Orlando | MCO | USA | 1,440 km | 2h 35m | F9, UA, WN |
| New Orleans | MSY | USA | 1,477 km | 2h 45m | WN |
| Tampa | TPA | USA | 1,491 km | 2h 36m | F9, UA, WN |
| Sarasota | SRQ | USA | 1,557 km | 2h 35m | WN |
| Dallas | DAL | USA | 1,634 km | 2h 55m | WN |
| Dallas | DFW | USA | 1,643 km | 3h 12m | AA, F9 |
| Fort Myers | RSW | USA | 1,650 km | 2h 52m | F9, UA, WN |
| Fort Lauderdale | FLL | USA | 1,708 km | 2h 56m | B6, F9, UA |
| Miami | MIA | USA | 1,737 km | 3h 1m | AA, F9, UA |
| Houston | IAH | USA | 1,756 km | 3h 10m | UA |
| Austin | AUS | USA | 1,890 km | 3h 8m | F9 |
| Denver | DEN | USA | 1,933 km | 3h 25m | F9, UA, WN |
| Cancun | CUN | Mexico | 2,307 km | 4h 1m | F9, UA |
| Salt Lake City | SLC | USA | 2,520 km | 4h 24m | DL |
| Phoenix | PHX | USA | 2,796 km | 4h 35m | AA, F9, WN |
| Punta Cana | PUJ | Dominican Republic | 2,838 km | 4h 10m | F9 |
| Las Vegas | LAS | USA | 2,936 km | 4h 40m | F9, UA, WN |
| San Juan | SJU | Puerto Rico | 2,959 km | 4h 25m | F9 |
| Seattle | SEA | USA | 3,252 km | 5h 7m | AS |
| Los Angeles | LAX | USA | 3,304 km | 5h 12m | AA, UA |
| San Francisco | SFO | USA | 3,480 km | 5h 30m | UA |
| Dublin | DUB | Ireland | 5,578 km | 7h 5m | EI |