Peoria Regional offers nonstop service to 22 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | ORD | USA | 208 km | 1h 20m | AA, UA |
| Charlotte | CLT | USA | 977 km | 2h 11m | AA |
| Dallas | DFW | USA | 1,082 km | 2h 25m | AA |
| Fort Walton Beach | VPS | USA | 1,163 km | 1h 59m | G4 |
| Denver | DEN | USA | 1,276 km | 2h 30m | G4, UA |
| Orlando | SFB | USA | 1,527 km | 2h 24m | G4 |
| Saint Petersburg | PIE | USA | 1,553 km | 2h 23m | G4 |
| Sarasota | SRQ | USA | 1,612 km | 2h 29m | G4 |
| Punta Gorda | PGD | USA | 1,681 km | 2h 39m | G4 |
| Mesa | AZA | USA | 2,111 km | 3h 29m | G4 |
| Las Vegas | LAS | USA | 2,273 km | 3h 40m | G4 |