Harrisburg International offers nonstop service to 19 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Philadelphia | PHL | USA | 133 km | 0h 58m | AA |
| Dulles | IAD | USA | 150 km | 0h 58m | UA |
| Boston | BOS | USA | 537 km | 1h 33m | AA |
| Detroit | DTW | USA | 596 km | 1h 36m | DL |
| Charlotte | CLT | USA | 663 km | 1h 49m | AA |
| Myrtle Beach | MYR | USA | 748 km | 1h 31m | G4 |
| Chicago | ORD | USA | 956 km | 2h 15m | AA, UA |
| Nashville | BNA | USA | 978 km | 1h 49m | G4 |
| Atlanta | ATL | USA | 998 km | 2h 4m | DL |
| Jacksonville | JAX | USA | 1,165 km | 2h 8m | G4 |
| Orlando | SFB | USA | 1,331 km | 2h 16m | G4 |
| Orlando | MCO | USA | 1,370 km | 2h 39m | F9 |
| Saint Petersburg | PIE | USA | 1,467 km | 2h 27m | G4 |
| Sarasota | SRQ | USA | 1,517 km | 2h 32m | G4 |
| Punta Gorda | PGD | USA | 1,549 km | 2h 38m | G4 |
| Fort Lauderdale | FLL | USA | 1,597 km | 2h 40m | G4 |
| Miami | MIA | USA | 1,630 km | 3h 6m | AA |
| Dallas | DFW | USA | 1,982 km | 3h 47m | AA |
| Los Angeles | LAX | USA | 3,733 km | 5h 17m | AA |