Harrisburg International offers nonstop service to 36 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Philadelphia | PHL | USA | 133 km | 0h 58m | AA |
| Dulles | IAD | USA | 150 km | 1h 0m | UA |
| Boston | BOS | USA | 537 km | 1h 34m | AA |
| Detroit | DTW | USA | 596 km | 1h 39m | DL |
| Charlotte | CLT | USA | 663 km | 1h 47m | AA |
| Myrtle Beach | MYR | USA | 748 km | 1h 32m | G4 |
| Chicago | ORD | USA | 956 km | 2h 20m | AA, UA |
| Nashville | BNA | USA | 978 km | 1h 55m | G4 |
| Atlanta | ATL | USA | 998 km | 2h 8m | DL |
| Jacksonville | JAX | USA | 1,165 km | 2h 14m | G4 |
| Orlando | SFB | USA | 1,331 km | 2h 21m | G4 |
| Saint Petersburg | PIE | USA | 1,467 km | 2h 33m | G4 |
| Sarasota | SRQ | USA | 1,517 km | 2h 36m | G4 |
| Punta Gorda | PGD | USA | 1,549 km | 2h 46m | G4 |
| Fort Lauderdale | FLL | USA | 1,597 km | 2h 47m | G4 |
| Miami | MIA | USA | 1,630 km | 3h 15m | AA |
| Dallas | DFW | USA | 1,982 km | 3h 47m | AA |
| Los Angeles | LAX | USA | 3,733 km | 5h 42m | AA |