Appleton offers nonstop service to 40 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | ORD | USA | 258 km | 1h 29m | AA, UA |
| Minneapolis | MSP | USA | 379 km | 1h 22m | DL |
| Detroit | DTW | USA | 476 km | 1h 25m | DL |
| Nashville | BNA | USA | 916 km | 1h 45m | G4 |
| Charlotte | CLT | USA | 1,194 km | 2h 30m | AA |
| Atlanta | ATL | USA | 1,230 km | 2h 12m | DL |
| Denver | DEN | USA | 1,421 km | 2h 37m | G4, UA |
| Dallas | DFW | USA | 1,461 km | 2h 58m | AA |
| Savannah | SAV | USA | 1,488 km | 2h 26m | G4 |
| Gulf Shores | GUF | USA | 1,552 km | 2h 32m | G4 |
| Orlando | SFB | USA | 1,835 km | 2h 52m | G4 |
| Orlando | MCO | USA | 1,869 km | 3h 5m | G4 |
| Saint Petersburg | PIE | USA | 1,886 km | 2h 59m | G4 |
| Sarasota | SRQ | USA | 1,946 km | 2h 59m | G4 |
| Punta Gorda | PGD | USA | 2,010 km | 3h 10m | G4 |
| Fort Myers | RSW | USA | 2,059 km | 3h 15m | G4 |
| Fort Lauderdale | FLL | USA | 2,154 km | 3h 26m | G4 |
| Mesa | AZA | USA | 2,337 km | 3h 56m | G4 |
| Las Vegas | LAS | USA | 2,430 km | 4h 0m | G4 |
| Santa Ana | SNA | USA | 2,781 km | 4h 35m | G4 |