Greater Rochester International offers nonstop service to 52 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| New York | EWR | USA | 396 km | 1h 26m | UA |
| New York | LGA | USA | 408 km | 1h 25m | DL |
| Philadelphia | PHL | USA | 413 km | 1h 27m | AA |
| New York | JFK | USA | 423 km | 1h 26m | B6, DL |
| Baltimore | BWI | USA | 446 km | 1h 23m | WN |
| Dulles | IAD | USA | 463 km | 1h 25m | UA |
| Washington | DCA | USA | 477 km | 1h 32m | AA |
| Detroit | DTW | USA | 477 km | 1h 27m | DL |
| Boston | BOS | USA | 550 km | 1h 30m | AA |
| Raleigh/Durham | RDU | USA | 811 km | 1h 42m | MX |
| Chicago | MDW | USA | 841 km | 2h 0m | WN |
| Chicago | ORD | USA | 850 km | 2h 16m | AA, UA |
| Concord | USA | USA | 898 km | 1h 52m | XP |
| Charlotte | CLT | USA | 922 km | 2h 9m | AA |
| Myrtle Beach | MYR | USA | 1,054 km | 2h 6m | MX |
| Charleston | CHS | USA | 1,155 km | 2h 20m | MX |
| Atlanta | ATL | USA | 1,207 km | 2h 20m | DL |
| Orlando | MCO | USA | 1,663 km | 2h 55m | B6, WN |
| Lakeland | LAL | USA | 1,724 km | 2h 53m | XP |
| Tampa | TPA | USA | 1,736 km | 3h 0m | MX, WN |
| Sarasota | SRQ | USA | 1,801 km | 3h 2m | G4 |
| Punta Gorda | PGD | USA | 1,840 km | 3h 5m | G4 |
| Fort Myers | RSW | USA | 1,878 km | 3h 4m | MX, WN |
| Fort Lauderdale | FLL | USA | 1,905 km | 2h 57m | G4, WN |
| Miami | MIA | USA | 1,937 km | 3h 25m | AA |
| Las Vegas | LAS | USA | 3,283 km | 5h 10m | WN |