South Bend Rgnl offers nonstop service to 21 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | ORD | USA | 135 km | 1h 11m | UA |
| Detroit | DTW | USA | 251 km | 1h 6m | DL |
| Minneapolis | MSP | USA | 661 km | 1h 45m | DL |
| Dulles | IAD | USA | 812 km | 1h 42m | MX, UA |
| Washington | DCA | USA | 848 km | 1h 47m | AA |
| Charlotte | CLT | USA | 858 km | 2h 2m | AA |
| Atlanta | ATL | USA | 909 km | 1h 58m | DL |
| New York | LGA | USA | 1,047 km | 1h 56m | AA |
| Boston | BOS | USA | 1,266 km | 2h 20m | AA |
| Dallas | DFW | USA | 1,361 km | 2h 45m | AA |
| Orlando | SFB | USA | 1,505 km | 2h 23m | G4 |
| Orlando | MCO | USA | 1,540 km | 2h 41m | MX |
| Saint Petersburg | PIE | USA | 1,564 km | 2h 27m | G4 |
| Sarasota | SRQ | USA | 1,624 km | 2h 30m | G4 |
| Punta Gorda | PGD | USA | 1,686 km | 2h 43m | G4 |
| Fort Myers | RSW | USA | 1,734 km | 2h 47m | MX |
| Fort Lauderdale | FLL | USA | 1,823 km | 2h 54m | G4 |
| Miami | MIA | USA | 1,849 km | 3h 0m | AA |
| Salt Lake City | SLC | USA | 2,146 km | 3h 35m | AA |
| Mesa | AZA | USA | 2,415 km | 3h 43m | G4 |
| Las Vegas | LAS | USA | 2,565 km | 4h 1m | G4 |