South Bend Rgnl offers nonstop service to 49 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | ORD | USA | 135 km | 1h 18m | AA, UA |
| Detroit | DTW | USA | 251 km | 1h 7m | DL |
| Minneapolis | MSP | USA | 661 km | 1h 44m | DL |
| Dulles | IAD | USA | 812 km | 1h 40m | MX, UA |
| Washington | DCA | USA | 848 km | 1h 50m | AA, DL |
| Charlotte | CLT | USA | 858 km | 2h 3m | AA |
| Atlanta | ATL | USA | 909 km | 2h 3m | DL |
| Raleigh/Durham | RDU | USA | 918 km | 1h 50m | DL |
| New York | EWR | USA | 1,023 km | 2h 7m | UA |
| New York | LGA | USA | 1,047 km | 2h 8m | AA, DL |
| Boston | BOS | USA | 1,266 km | 2h 18m | AA, DL |
| Dallas | DFW | USA | 1,361 km | 2h 56m | AA |
| Orlando | SFB | USA | 1,505 km | 2h 24m | G4 |
| Orlando | MCO | USA | 1,540 km | 2h 41m | MX |
| Saint Petersburg | PIE | USA | 1,564 km | 2h 29m | G4 |
| Sarasota | SRQ | USA | 1,624 km | 2h 32m | G4 |
| Punta Gorda | PGD | USA | 1,686 km | 2h 46m | G4 |
| Fort Myers | RSW | USA | 1,734 km | 2h 47m | MX |
| Fort Lauderdale | FLL | USA | 1,823 km | 2h 54m | G4 |
| Miami | MIA | USA | 1,849 km | 2h 59m | AA, DL |
| Salt Lake City | SLC | USA | 2,146 km | 3h 43m | AA |
| Mesa | AZA | USA | 2,415 km | 3h 57m | G4 |
| Las Vegas | LAS | USA | 2,565 km | 4h 10m | G4 |
| San Francisco | SFO | USA | 3,106 km | 4h 54m | UA |