Lexington offers nonstop service to 46 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Charlotte | CLT | USA | 452 km | 1h 38m | AA |
| Detroit | DTW | USA | 474 km | 1h 27m | DL |
| Atlanta | ATL | USA | 488 km | 1h 33m | DL |
| Chicago | ORD | USA | 520 km | 1h 48m | AA, UA |
| Washington | DCA | USA | 665 km | 1h 37m | DL |
| Philadelphia | PHL | USA | 835 km | 1h 52m | AA |
| New York | LGA | USA | 971 km | 2h 4m | DL |
| New York | JFK | USA | 974 km | 2h 10m | AA |
| Baton Rouge | BTR | USA | 1,027 km | 2h 1m | DL |
| New Orleans | MSY | USA | 1,034 km | 2h 8m | AA |
| Minneapolis | MSP | USA | 1,045 km | 2h 28m | DL |
| Orlando | SFB | USA | 1,073 km | 1h 51m | G4 |
| Saint Petersburg | PIE | USA | 1,136 km | 1h 59m | G4 |
| Sarasota | SRQ | USA | 1,196 km | 2h 0m | G4 |
| Boston | BOS | USA | 1,250 km | 2h 26m | AA |
| Punta Gorda | PGD | USA | 1,256 km | 2h 9m | G4 |
| Dallas | DFW | USA | 1,263 km | 2h 40m | AA |
| Fort Lauderdale | FLL | USA | 1,391 km | 2h 24m | G4 |
| Miami | MIA | USA | 1,417 km | 2h 29m | AA |
| Austin | AUS | USA | 1,483 km | 2h 49m | DL |
| Denver | DEN | USA | 1,748 km | 3h 20m | UA |
| Phoenix | PHX | USA | 2,521 km | 3h 32m | AA |
| Los Angeles | LAX | USA | 3,065 km | 4h 33m | AA |