Lexington offers nonstop service to 21 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Charlotte | CLT | USA | 452 km | 1h 38m | AA |
| Detroit | DTW | USA | 474 km | 1h 25m | DL |
| Atlanta | ATL | USA | 488 km | 1h 33m | DL |
| Chicago | ORD | USA | 520 km | 1h 46m | AA, UA |
| Birmingham | BHM | USA | 533 km | 1h 30m | AA |
| Washington | DCA | USA | 665 km | 1h 37m | DL |
| Myrtle Beach | MYR | USA | 704 km | 1h 25m | G4 |
| Philadelphia | PHL | USA | 835 km | 1h 54m | AA |
| Fort Walton Beach | VPS | USA | 855 km | 1h 39m | G4 |
| New York | LGA | USA | 971 km | 2h 0m | DL |
| New Orleans | MSY | USA | 1,034 km | 2h 15m | AA |
| Minneapolis | MSP | USA | 1,045 km | 2h 0m | DL |
| Orlando | SFB | USA | 1,073 km | 1h 53m | G4 |
| Saint Petersburg | PIE | USA | 1,136 km | 1h 58m | G4 |
| Sarasota | SRQ | USA | 1,196 km | 2h 1m | G4 |
| Punta Gorda | PGD | USA | 1,256 km | 2h 10m | G4 |
| Dallas | DFW | USA | 1,263 km | 2h 35m | AA |
| Fort Lauderdale | FLL | USA | 1,391 km | 2h 21m | G4 |
| Miami | MIA | USA | 1,417 km | 2h 29m | AA |
| Denver | DEN | USA | 1,748 km | 3h 13m | UA |
| Las Vegas | LAS | USA | 2,713 km | 4h 16m | G4 |