Cincinnati Northern Kentucky International offers nonstop service to 118 destinations, served by 12 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Detroit | DTW | USA | 367 km | 1h 14m | DL |
| Nashville | BNA | USA | 369 km | 1h 15m | WN |
| Chicago | MDW | USA | 400 km | 1h 10m | WN |
| Chicago | ORD | USA | 425 km | 1h 38m | AA, UA |
| Greenville | GSP | USA | 510 km | 1h 18m | MX |
| Charlotte | CLT | USA | 539 km | 1h 37m | AA |
| Atlanta | ATL | USA | 601 km | 1h 36m | DL, F9 |
| Dulles | IAD | USA | 624 km | 1h 36m | UA |
| Raleigh/Durham | RDU | USA | 627 km | 1h 27m | DL |
| Washington | DCA | USA | 660 km | 1h 37m | AA, DL |
| Toronto | YYZ | Canada | 664 km | 1h 30m | AC |
| Augusta | AGS | USA | 675 km | 2h 0m | DL |
| Baltimore | BWI | USA | 691 km | 1h 30m | WN |
| Myrtle Beach | MYR | USA | 787 km | 1h 31m | G4 |
| Charleston | CHS | USA | 801 km | 1h 39m | G4, MX |
| Philadelphia | PHL | USA | 815 km | 1h 48m | AA |
| Savannah | SAV | USA | 828 km | 1h 35m | G4 |
| New York | EWR | USA | 914 km | 2h 3m | DL, G4, UA |
| New York | LGA | USA | 941 km | 2h 1m | DL |
| New York | JFK | USA | 946 km | 2h 7m | AA, DL |
| Minneapolis | MSP | USA | 958 km | 2h 2m | DL, SY |
| Fort Walton Beach | VPS | USA | 965 km | 1h 48m | G4 |
| Jacksonville | JAX | USA | 988 km | 1h 49m | G4 |
| Gulf Shores | GUF | USA | 1,010 km | 1h 53m | G4 |
| Hartford | BDL | USA | 1,063 km | 2h 2m | MX |
| New Orleans | MSY | USA | 1,129 km | 2h 10m | G4 |
| Montreal | YUL | Canada | 1,145 km | 1h 53m | AC |
| Providence | PVD | USA | 1,160 km | 2h 4m | MX |
| Orlando | SFB | USA | 1,183 km | 2h 4m | G4 |
| Boston | BOS | USA | 1,208 km | 2h 16m | AA, DL |
| Orlando | MCO | USA | 1,218 km | 2h 13m | DL, F9, G4, WN |
| Tampa | TPA | USA | 1,244 km | 2h 11m | DL, F9 |
| Saint Petersburg | PIE | USA | 1,249 km | 2h 9m | G4 |
| Melbourne | MLB | USA | 1,270 km | 2h 8m | G4 |
| Portland | PWM | USA | 1,302 km | 2h 13m | MX |
| Dallas | DFW | USA | 1,306 km | 2h 40m | AA, F9 |
| Sarasota | SRQ | USA | 1,308 km | 2h 14m | G4 |
| Punta Gorda | PGD | USA | 1,368 km | 2h 20m | G4 |
| Houston | IAH | USA | 1,403 km | 2h 43m | UA |
| Fort Myers | RSW | USA | 1,415 km | 2h 24m | DL, F9 |
| West Palm Beach | DJT | USA | 1,436 km | 2h 28m | G4 |
| Fort Lauderdale | FLL | USA | 1,500 km | 2h 34m | DL, F9, G4 |
| Miami | MIA | USA | 1,526 km | 2h 40m | AA, F9 |
| Austin | AUS | USA | 1,542 km | 2h 50m | DL, G4, WN |
| Key West | EYW | USA | 1,631 km | 2h 35m | G4 |
| Lubbock | LBB | USA | 1,649 km | 3h 3m | AA |
| Denver | DEN | USA | 1,721 km | 3h 5m | F9, UA, WN |
| Cancun | CUN | Mexico | 2,008 km | 3h 30m | AA, DL, F9, VB |
| Salt Lake City | SLC | USA | 2,334 km | 3h 53m | DL |
| Mesa | AZA | USA | 2,500 km | 4h 12m | G4 |
| Phoenix | PHX | USA | 2,524 km | 4h 17m | AA, WN |
| Las Vegas | LAS | USA | 2,700 km | 4h 24m | DL, F9, G4 |
| Punta Cana | PUJ | Dominican Republic | 2,763 km | 3h 55m | F9 |
| San Diego | SAN | USA | 3,002 km | 4h 45m | MX |
| Los Angeles | LAX | USA | 3,058 km | 4h 52m | DL |
| Seattle | SEA | USA | 3,160 km | 5h 1m | AS, DL |
| San Francisco | SFO | USA | 3,278 km | 5h 15m | MX, UA |
| London | LHR | United Kingdom | 6,377 km | 7h 40m | BA |
| Paris | CDG | France | 6,687 km | 8h 5m | DL |