Fort Wayne offers nonstop service to 14 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Detroit | DTW | USA | 204 km | 1h 1m | DL |
| Chicago | ORD | USA | 252 km | 1h 20m | AA, UA |
| Charlotte | CLT | USA | 740 km | 1h 57m | AA |
| Minneapolis | MSP | USA | 784 km | 1h 57m | DL |
| Atlanta | ATL | USA | 818 km | 1h 56m | DL |
| Myrtle Beach | MYR | USA | 981 km | 1h 44m | G4 |
| Dallas | DFW | USA | 1,383 km | 2h 50m | AA |
| Orlando | SFB | USA | 1,401 km | 2h 16m | G4 |
| Saint Petersburg | PIE | USA | 1,468 km | 2h 22m | G4 |
| Sarasota | SRQ | USA | 1,527 km | 2h 22m | G4 |
| Punta Gorda | PGD | USA | 1,587 km | 2h 31m | G4 |
| Fort Lauderdale | FLL | USA | 1,718 km | 2h 48m | G4 |
| Mesa | AZA | USA | 2,489 km | 3h 47m | G4 |
| Las Vegas | LAS | USA | 2,654 km | 4h 4m | G4 |