Fort Wayne offers nonstop service to 26 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Detroit | DTW | USA | 204 km | 1h 4m | DL |
| Chicago | ORD | USA | 252 km | 1h 30m | AA, UA |
| Charlotte | CLT | USA | 740 km | 2h 0m | AA |
| Minneapolis | MSP | USA | 784 km | 1h 59m | DL |
| Atlanta | ATL | USA | 818 km | 1h 53m | DL |
| Dallas | DFW | USA | 1,383 km | 2h 53m | AA |
| Orlando | SFB | USA | 1,401 km | 2h 19m | G4 |
| Saint Petersburg | PIE | USA | 1,468 km | 2h 24m | G4 |
| Sarasota | SRQ | USA | 1,527 km | 2h 29m | G4 |
| Punta Gorda | PGD | USA | 1,587 km | 2h 37m | G4 |
| Fort Lauderdale | FLL | USA | 1,718 km | 2h 51m | G4 |
| Mesa | AZA | USA | 2,489 km | 4h 9m | G4 |
| Las Vegas | LAS | USA | 2,654 km | 4h 11m | G4 |