General Mitchell International offers nonstop service to 34 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | ORD | USA | 107 km | 1h 10m | AA, UA |
| Chicago | MDW | USA | 129 km | 0h 50m | WN |
| Detroit | DTW | USA | 382 km | 1h 12m | DL |
| Minneapolis | MSP | USA | 477 km | 1h 21m | DL, SY |
| Saint Louis | STL | USA | 510 km | 1h 20m | WN |
| Kansas City | MCI | USA | 701 km | 1h 30m | WN |
| Nashville | BNA | USA | 764 km | 1h 35m | WN |
| Washington | DCA | USA | 1,020 km | 1h 55m | WN, AA |
| Baltimore | BWI | USA | 1,031 km | 1h 50m | WN |
| Charlotte | CLT | USA | 1,047 km | 2h 11m | AA |
| Atlanta | ATL | USA | 1,076 km | 2h 7m | DL, F9 |
| Philadelphia | PHL | USA | 1,110 km | 2h 12m | AA |
| New York | EWR | USA | 1,166 km | 2h 21m | UA |
| New York | LGA | USA | 1,188 km | 2h 17m | DL |
| New York | JFK | USA | 1,199 km | 2h 26m | DL |
| Dallas | DAL | USA | 1,368 km | 2h 25m | WN |
| Dallas | DFW | USA | 1,372 km | 2h 42m | AA |
| Boston | BOS | USA | 1,383 km | 2h 23m | DL, B6 |
| Denver | DEN | USA | 1,441 km | 2h 40m | F9, UA, WN |
| Houston | IAH | USA | 1,583 km | 3h 3m | UA |
| Austin | AUS | USA | 1,659 km | 2h 50m | WN |
| Orlando | MCO | USA | 1,716 km | 2h 45m | F9, WN, SY |
| Tampa | TPA | USA | 1,729 km | 2h 45m | F9, WN |
| Sarasota | SRQ | USA | 1,792 km | 2h 45m | WN |
| Fort Myers | RSW | USA | 1,905 km | 2h 55m | WN, SY |
| Fort Lauderdale | FLL | USA | 2,000 km | 3h 10m | WN |
| Salt Lake City | SLC | USA | 2,006 km | 3h 34m | DL |
| Miami | MIA | USA | 2,025 km | 3h 27m | AA, WN |
| Phoenix | PHX | USA | 2,348 km | 3h 45m | AA, F9, WN |
| Cancun | CUN | Mexico | 2,431 km | 3h 50m | WN, SY |
| Las Vegas | LAS | USA | 2,451 km | 3h 50m | F9, WN, SY |
| Seattle | SEA | USA | 2,725 km | 4h 28m | AS |
| San Diego | SAN | USA | 2,798 km | 4h 10m | WN |
| Punta Cana | PUJ | Dominican Republic | 3,269 km | 4h 35m | SY |