Port Columbus International offers nonstop service to 55 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Detroit | DTW | USA | 248 km | 1h 7m | DL |
| Chicago | MDW | USA | 454 km | 1h 15m | WN |
| Chicago | ORD | USA | 476 km | 1h 37m | AA, UA |
| Dulles | IAD | USA | 481 km | 1h 24m | UA |
| Toronto | YYZ | Canada | 491 km | 1h 22m | AC |
| Washington | DCA | USA | 518 km | 1h 26m | AA, WN |
| Baltimore | BWI | USA | 541 km | 1h 20m | WN |
| Nashville | BNA | USA | 542 km | 1h 20m | WN |
| Charlotte | CLT | USA | 557 km | 1h 38m | AA |
| Greenville | GSP | USA | 569 km | 1h 20m | MX |
| Raleigh/Durham | RDU | USA | 582 km | 1h 25m | MX |
| Philadelphia | PHL | USA | 653 km | 1h 39m | AA |
| Saint Louis | STL | USA | 660 km | 1h 30m | WN |
| Norfolk | ORF | USA | 676 km | 1h 30m | MX |
| Atlanta | ATL | USA | 719 km | 1h 41m | DL, WN, F9 |
| New York | EWR | USA | 743 km | 1h 53m | UA |
| New York | LGA | USA | 769 km | 1h 49m | AA, DL |
| Cedar Rapids | CID | USA | 771 km | 1h 40m | AA |
| New York | JFK | USA | 776 km | 1h 57m | AA, DL |
| Myrtle Beach | MYR | USA | 784 km | 1h 30m | WN |
| Charleston | CHS | USA | 829 km | 1h 43m | MX |
| Hartford | BDL | USA | 884 km | 1h 46m | MX |
| Savannah | SAV | USA | 885 km | 1h 50m | MX |
| Montreal | YUL | Canada | 962 km | 1h 45m | AC |
| Providence | PVD | USA | 983 km | 1h 50m | MX |
| Minneapolis | MSP | USA | 1,006 km | 2h 6m | DL, SY |
| Kansas City | MCI | USA | 1,018 km | 1h 55m | WN |
| Boston | BOS | USA | 1,028 km | 2h 2m | DL, AA |
| Jacksonville | JAX | USA | 1,060 km | 2h 4m | MX |
| Panama City | ECP | USA | 1,102 km | 2h 0m | WN |
| Portland | PWM | USA | 1,119 km | 1h 56m | MX |
| Lincoln | LNK | USA | 1,179 km | 2h 20m | AA |
| Orlando | MCO | USA | 1,291 km | 2h 15m | DL, F9, NK, WN |
| Tampa | TPA | USA | 1,333 km | 2h 15m | WN, MX |
| Sarasota | SRQ | USA | 1,399 km | 2h 20m | WN |
| Dallas | DAL | USA | 1,480 km | 2h 35m | WN |
| Dallas | DFW | USA | 1,490 km | 2h 58m | AA |
| Fort Myers | RSW | USA | 1,497 km | 2h 25m | WN, MX |
| West Palm Beach | PBI | USA | 1,499 km | 2h 37m | MX |
| Fort Lauderdale | FLL | USA | 1,565 km | 2h 35m | NK, WN, F9 |
| Houston | IAH | USA | 1,586 km | 3h 3m | UA |
| Miami | MIA | USA | 1,593 km | 2h 44m | AA, WN |
| Houston | HOU | USA | 1,610 km | 2h 45m | WN |
| Austin | AUS | USA | 1,727 km | 2h 55m | WN, DL, AA |
| Denver | DEN | USA | 1,858 km | 3h 14m | F9, UA, WN |
| Cancun | CUN | Mexico | 2,135 km | 3h 30m | WN, AA |
| Salt Lake City | SLC | USA | 2,460 km | 4h 11m | DL |
| Phoenix | PHX | USA | 2,687 km | 4h 19m | AA, WN |
| Las Vegas | LAS | USA | 2,849 km | 4h 25m | WN |
| San Diego | SAN | USA | 3,161 km | 4h 45m | WN |
| Santa Ana | SNA | USA | 3,176 km | 5h 4m | MX |
| Los Angeles | LAX | USA | 3,211 km | 5h 5m | AA, UA |
| Seattle | SEA | USA | 3,244 km | 5h 10m | AS |
| Portland | PDX | USA | 3,272 km | 5h 4m | AA |
| San Francisco | SFO | USA | 3,413 km | 5h 6m | UA |