Quad City Intl offers nonstop service to 22 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | ORD | USA | 224 km | 1h 20m | AA, UA |
| Atlanta | ATL | USA | 1,018 km | 2h 1m | DL |
| Charlotte | CLT | USA | 1,084 km | 2h 22m | AA |
| Dallas | DFW | USA | 1,111 km | 2h 28m | AA |
| Denver | DEN | USA | 1,209 km | 2h 42m | UA |
| Orlando | SFB | USA | 1,638 km | 2h 30m | G4 |
| Saint Petersburg | PIE | USA | 1,662 km | 2h 32m | G4 |
| Sarasota | SRQ | USA | 1,721 km | 2h 44m | G4 |
| Punta Gorda | PGD | USA | 1,790 km | 2h 47m | G4 |
| Mesa | AZA | USA | 2,072 km | 3h 31m | G4 |
| Las Vegas | LAS | USA | 2,214 km | 3h 34m | G4 |