Portland International offers nonstop service to 168 destinations, served by 18 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Eugene | EUG | USA | 169 km | 0h 51m | AS |
| Redmond | RDM | USA | 187 km | 0h 50m | AS |
| Seattle | SEA | USA | 207 km | 1h 3m | AS, DL |
| Seattle | BFI | USA | 216 km | 0h 50m | X4 |
| Everett | PAE | USA | 259 km | 0h 58m | AS |
| Wenatchee | EAT | USA | 272 km | 0h 57m | AS |
| Pasco | PSC | USA | 279 km | 0h 56m | AS |
| Pendleton | PDT | USA | 292 km | 0h 50m | 4B |
| Bellingham | BLI | USA | 356 km | 1h 0m | AS |
| Medford | MFR | USA | 358 km | 1h 4m | AS |
| Vancouver | YVR | Canada | 403 km | 1h 18m | AC, AS |
| Spokane | GEG | USA | 448 km | 1h 10m | AS |
| Boise | BOI | USA | 553 km | 1h 18m | AS |
| Missoula | MSO | USA | 672 km | 1h 35m | AS |
| Kalispell | FCA | USA | 702 km | 1h 27m | AS |
| Reno | RNO | USA | 714 km | 1h 29m | AS |
| Sacramento | SMF | USA | 770 km | 1h 35m | AS, WN |
| Santa Rosa | STS | USA | 786 km | 1h 44m | AS |
| Idaho Falls | IDA | USA | 866 km | 1h 47m | AS |
| Oakland | OAK | USA | 875 km | 1h 45m | AS, WN |
| Calgary | YYC | Canada | 884 km | 2h 0m | WS |
| San Francisco | SFO | USA | 885 km | 1h 54m | AS, F9, UA |
| Bozeman | BZN | USA | 890 km | 1h 40m | AS |
| San Jose | SJC | USA | 914 km | 1h 50m | AS, WN |
| Jackson | JAC | USA | 965 km | 2h 0m | AS |
| Fresno | FAT | USA | 1,008 km | 2h 0m | AS |
| Salt Lake City | SLC | USA | 1,013 km | 1h 53m | AS, DL |
| Provo | PVU | USA | 1,068 km | 1h 50m | G4 |
| Billings | BIL | USA | 1,093 km | 1h 50m | AS |
| San Luis Obispo | SBP | USA | 1,161 km | 2h 10m | AS |
| Las Vegas | LAS | USA | 1,227 km | 2h 18m | AS, F9, WN |
| Santa Barbara | SBA | USA | 1,260 km | 2h 13m | AS |
| Burbank | BUR | USA | 1,315 km | 2h 20m | AS |
| Los Angeles | LAX | USA | 1,341 km | 2h 29m | AA, AS, DL, F9 |
| Ontario | ONT | USA | 1,349 km | 2h 21m | AS, F9 |
| Long Beach | LGB | USA | 1,360 km | 2h 20m | WN |
| Hayden | HDN | USA | 1,372 km | 2h 25m | AS |
| Santa Ana | SNA | USA | 1,382 km | 2h 33m | AS |
| Palm Springs | PSP | USA | 1,405 km | 2h 34m | AS |
| San Diego | SAN | USA | 1,500 km | 2h 33m | AS, WN |
| Denver | DEN | USA | 1,595 km | 2h 30m | AS, F9, UA, WN |
| Phoenix | PHX | USA | 1,624 km | 2h 38m | AA, AS, WN |
| Mesa | AZA | USA | 1,653 km | 2h 48m | G4 |
| Albuquerque | ABQ | USA | 1,786 km | 2h 48m | AS |
| Tucson | TUS | USA | 1,801 km | 2h 55m | AS |
| Minneapolis | MSP | USA | 2,295 km | 3h 20m | AS, DL, SY |
| Kansas City | MCI | USA | 2,383 km | 3h 28m | AS, WN |
| Anchorage | ANC | USA | 2,482 km | 3h 57m | AS |
| Dallas | DFW | USA | 2,600 km | 3h 50m | AA, AS |
| Dallas | DAL | USA | 2,617 km | 3h 35m | WN |
| Fairbanks | FAI | USA | 2,639 km | 3h 56m | AS |
| San Jose Cabo | SJD | Mexico | 2,747 km | 4h 8m | AS |
| Saint Louis | STL | USA | 2,747 km | 3h 54m | AS, WN |
| Austin | AUS | USA | 2,759 km | 4h 3m | AS |
| Chicago | ORD | USA | 2,798 km | 4h 8m | AA, AS, UA |
| Chicago | MDW | USA | 2,818 km | 3h 50m | WN |
| Houston | IAH | USA | 2,936 km | 4h 10m | AS, UA |
| Detroit | DTW | USA | 3,142 km | 4h 15m | DL |
| Nashville | BNA | USA | 3,174 km | 4h 23m | AS |
| Puerto Vallarta | PVR | Mexico | 3,186 km | 4h 31m | AS |
| Columbus | CMH | USA | 3,272 km | 4h 48m | AA |
| Guadalajara | GDL | Mexico | 3,293 km | 4h 38m | Y4 |
| Atlanta | ATL | USA | 3,493 km | 4h 40m | AS, DL |
| Charlotte | CLT | USA | 3,672 km | 4h 51m | AA |
| Dulles | IAD | USA | 3,745 km | 4h 52m | UA |
| Washington | DCA | USA | 3,781 km | 4h 57m | AS |
| Baltimore | BWI | USA | 3,794 km | 5h 10m | AS, WN |
| Philadelphia | PHL | USA | 3,871 km | 5h 14m | AA, AS |
| New York | EWR | USA | 3,915 km | 5h 20m | AS, UA |
| New York | JFK | USA | 3,947 km | 5h 27m | AS, DL |
| Tampa | TPA | USA | 4,017 km | 5h 15m | AS |
| Orlando | MCO | USA | 4,078 km | 5h 29m | AS |
| Boston | BOS | USA | 4,081 km | 5h 27m | AS, B6 |
| Kahului | OGG | USA | 4,123 km | 6h 7m | AS |
| Honolulu | HNL | USA | 4,188 km | 6h 10m | AS |
| Kailua-Kona | KOA | USA | 4,195 km | 6h 8m | AS |
| Kauai Island | LIH | USA | 4,234 km | 6h 10m | AS |
| Cancun | CUN | Mexico | 4,239 km | 5h 53m | AS |
| Fort Lauderdale | FLL | USA | 4,335 km | 5h 46m | AS |
| Miami | MIA | USA | 4,345 km | 5h 43m | AA, AS |
| Reykjavik | KEF | Iceland | 6,013 km | 7h 30m | FI |
| London | LHR | United Kingdom | 7,908 km | 9h 35m | BA |
| Amsterdam | AMS | Netherlands | 8,052 km | 9h 35m | KL |
| Frankfurt | FRA | Germany | 8,409 km | 10h 15m | DE |