Jackson Hole offers nonstop service to 34 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Salt Lake City | SLC | USA | 329 km | 1h 13m | DL |
| Denver | DEN | USA | 653 km | 1h 42m | UA |
| Portland | PDX | USA | 965 km | 2h 1m | AS |
| Seattle | SEA | USA | 998 km | 2h 26m | AS |
| San Francisco | SFO | USA | 1,187 km | 2h 34m | AS, UA |
| Los Angeles | LAX | USA | 1,261 km | 2h 31m | AA, DL, UA |
| San Diego | SAN | USA | 1,331 km | 2h 45m | AS |
| Minneapolis | MSP | USA | 1,404 km | 2h 19m | DL |
| Dallas | DFW | USA | 1,683 km | 2h 51m | AA |
| Chicago | ORD | USA | 1,870 km | 3h 10m | AA, UA |
| Houston | IAH | USA | 2,035 km | 3h 22m | UA |
| Atlanta | ATL | USA | 2,528 km | 3h 40m | DL |
| Charlotte | CLT | USA | 2,712 km | 4h 4m | AA |
| Dulles | IAD | USA | 2,816 km | 4h 15m | UA |
| New York | EWR | USA | 3,014 km | 4h 21m | UA |
| New York | JFK | USA | 3,047 km | 4h 29m | AA |
| Boston | BOS | USA | 3,211 km | 4h 50m | UA |