Tucson International offers nonstop service to 38 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Phoenix | PHX | USA | 176 km | 1h 0m | AA, WN |
| Las Vegas | LAS | USA | 586 km | 1h 25m | WN |
| San Diego | SAN | USA | 592 km | 1h 25m | WN |
| Santa Ana | SNA | USA | 670 km | 1h 42m | AS |
| Los Angeles | LAX | USA | 726 km | 1h 48m | AA, DL, WN |
| Salt Lake City | SLC | USA | 966 km | 2h 3m | DL |
| Denver | DEN | USA | 1,026 km | 1h 57m | UA, WN |
| San Francisco | SFO | USA | 1,210 km | 2h 32m | UA |
| Sacramento | SMF | USA | 1,210 km | 2h 10m | WN |
| Dallas | DFW | USA | 1,308 km | 2h 23m | AA |
| Dallas | DAL | USA | 1,325 km | 2h 10m | WN |
| Houston | IAH | USA | 1,506 km | 2h 24m | UA |
| Houston | HOU | USA | 1,520 km | 2h 15m | WN |
| Portland | PDX | USA | 1,801 km | 3h 13m | AS |
| Seattle | SEA | USA | 1,955 km | 3h 22m | AS, DL |
| Minneapolis | MSP | USA | 2,088 km | 3h 4m | DL, SY |
| Chicago | ORD | USA | 2,312 km | 3h 44m | AA, UA |
| Chicago | MDW | USA | 2,317 km | 3h 15m | WN |
| Atlanta | ATL | USA | 2,478 km | 3h 32m | DL |