San Luis County Regional Airport offers nonstop service to 18 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Los Angeles | LAX | USA | 250 km | 1h 23m | UA |
| San Francisco | SFO | USA | 306 km | 1h 6m | UA |
| San Diego | SAN | USA | 422 km | 1h 19m | AS |
| Las Vegas | LAS | USA | 506 km | 1h 24m | AS |
| Phoenix | PHX | USA | 819 km | 1h 46m | AA |
| Portland | PDX | USA | 1,161 km | 2h 4m | AS |
| Seattle | SEA | USA | 1,362 km | 2h 30m | AS |
| Denver | DEN | USA | 1,498 km | 2h 36m | UA |
| Dallas | DFW | USA | 2,189 km | 3h 29m | AA |