Licenciado Gustavo Diaz Ordaz International offers nonstop service to 105 destinations, served by 16 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Guadalajara | GDL | Mexico | 202 km | 0h 58m | VB, Y4 |
| Aguascalientes | AGU | Mexico | 324 km | 0h 57m | Y4 |
| Leon/Guanajuato | BJX | Mexico | 393 km | 1h 4m | Y4 |
| San Luis Potosi | SLP | Mexico | 480 km | 1h 5m | Y4 |
| Queretaro | QRO | Mexico | 527 km | 1h 16m | Y4 |
| Cabo San Lucas | CSW | Mexico | 546 km | 1h 30m | SEN |
| Toluca | TLC | Mexico | 612 km | 1h 24m | VB, Y4 |
| Mexico City | NLU | Mexico | 659 km | 1h 30m | AM, VB, XN |
| Mexico City | MEX | Mexico | 660 km | 1h 44m | AM, VB, Y4 |
| Puebla | PBC | Mexico | 740 km | 1h 29m | Y4 |
| Monterrey | MTY | Mexico | 771 km | 1h 37m | VB, Y4 |
| Ciudad Juarez | CJS | Mexico | 1,219 km | 2h 11m | VB |
| Austin | AUS | USA | 1,300 km | 2h 15m | WN |
| Houston | HOU | USA | 1,411 km | 2h 20m | WN |
| Houston | IAH | USA | 1,433 km | 2h 25m | UA |
| Phoenix | PHX | USA | 1,563 km | 2h 40m | AA, WN |
| Dallas | DFW | USA | 1,579 km | 2h 50m | AA |
| Mexicali | MXL | Mexico | 1,654 km | 2h 37m | Y4 |
| Tijuana | TIJ | Mexico | 1,755 km | 2h 47m | VB, Y4 |
| San Diego | SAN | USA | 1,785 km | 3h 0m | AS, WN |
| Santa Ana | SNA | USA | 1,903 km | 3h 10m | WN |
| Las Vegas | LAS | USA | 1,960 km | 3h 10m | WN |
| Los Angeles | LAX | USA | 1,960 km | 3h 16m | AA, AS, DL, UA |
| Denver | DEN | USA | 2,126 km | 3h 25m | UA, WN |
| Salt Lake City | SLC | USA | 2,318 km | 3h 37m | DL |
| San Jose | SJC | USA | 2,453 km | 3h 56m | AS |
| Saint Louis | STL | USA | 2,458 km | 3h 35m | WN |
| San Francisco | SFO | USA | 2,502 km | 4h 0m | AS, UA |
| Atlanta | ATL | USA | 2,504 km | 3h 40m | DL |
| Sacramento | SMF | USA | 2,538 km | 4h 0m | WN |
| Chicago | ORD | USA | 2,868 km | 4h 24m | AA, UA |
| Minneapolis | MSP | USA | 2,904 km | 4h 11m | DL, SY |
| Detroit | DTW | USA | 3,147 km | 4h 20m | DL |
| Portland | PDX | USA | 3,186 km | 4h 50m | AS |
| Regina | YQR | Canada | 3,302 km | 4h 50m | WS |
| Winnipeg | YWG | Canada | 3,319 km | 4h 50m | WS |
| Seattle | SEA | USA | 3,343 km | 5h 9m | AS, DL |
| Hamilton | YHM | Canada | 3,430 km | 4h 32m | PD |
| Calgary | YYC | Canada | 3,464 km | 5h 10m | AC, F8, WS |
| Kelowna | YLW | Canada | 3,479 km | 5h 15m | WS |
| Toronto | YYZ | Canada | 3,485 km | 4h 50m | AC, F8, PD, TS, WS |
| Vancouver | YXX | Canada | 3,494 km | 5h 20m | WS |
| Saskatoon | YXE | Canada | 3,496 km | 5h 10m | WS |
| Victoria | YYJ | Canada | 3,501 km | 5h 15m | WS |
| Vancouver | YVR | Canada | 3,542 km | 5h 25m | AC, F8, WS |
| Comox | YQQ | Canada | 3,659 km | 5h 30m | WS |
| New York | EWR | USA | 3,679 km | 5h 4m | UA |
| Edmonton | YEG | Canada | 3,690 km | 5h 30m | F8, PD, WS |
| Ottawa | YOW | Canada | 3,845 km | 5h 10m | PD, WS |
| Prince George | YXS | Canada | 3,972 km | 5h 50m | WS |
| Montreal | YUL | Canada | 3,978 km | 4h 55m | AC, TS, WS |
| Quebec | YQB | Canada | 4,212 km | 5h 5m | TS |
| Tokyo | NRT | Japan | 10,706 km | 14h 45m | AM |